| Short Description : | Recombinant-Human BTN1A1/Butyrophilin-C-hFc&His protein was developed in hek293 cells using the region Ala 27-Arg 242. For use in research applications. |
| Host: | HEK293 cells |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Conjugation: | Unconjugated |
| Formulation: | Lyophilised from a 0.22 Mu m filtered solution of PBS, pH 7.4. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Immunoreactivity: | Measured by its ability to inhibit Anti-CD3-induced proliferation of Jurkat Human acute T lymphocyte leukemia cells. The ED50 for this effect is 0.13-0.52 ng/mL. |
| Determination Method: | < 1.0 EU/Mu g of the protein by LAL method. |
| Gene Symbol: | BTN1A1 |
| Gene ID: | 696 |
| Uniprot ID: | BT1A1_HUMAN |
| Immunogen: | Recombinant Human BTN1A1/Butyrophilin Protein is produced by HEK293 expression system. The target protein is expressed with sequence (Ala 27-Arg 242 ) of human BTN1A1/Butyrophilin (Accession #NP_001723.2) fused with an Fc, 6×His tag at the C-terminus |
| Immunogen Region: | Ala 27-Arg 242 |
| Immunogen Sequence: | APFDVIGPPEPILAVVGEDA ELPCRLSPNASAEHLELRWF RKKVSPAVLVHRDGREQEAE QMPEYRGRATLVQDGIAKGR VALRIRGVRVSDDGEYTCFF REDGSYEEALVHLKVAALGS DPHISMQVQENGEICLECTS VGWYPEPQVQWRTSKGEKFP STSESRNPDEEGLFTVAASV IIRDTSAKNVSCYIQNLLLG QEKKVEISIPASSLPR |
| Post Translational Modifications | N-glycosylated. |
| Function | May function in the secretion of milk-fat droplets. May act as a specific membrane-associated receptor for the association of cytoplasmic droplets with the apical plasma membrane. Inhibits the proliferation of CD4 and CD8 T-cells activated by anti-CD3 antibodies, T-cell metabolism and IL2 and IFNG secretion. |
| Protein Name | Butyrophilin Subfamily 1 Member A1Bt |
| Database Links | Reactome: R-HSA-8851680 |
| Cellular Localisation | MembraneSingle-Pass Type I Membrane ProteinSecreted |
| Alternative Protein Names | Butyrophilin Subfamily 1 Member A1 proteinBt proteinBTN1A1 proteinBTN protein |
Information sourced from Uniprot.org
