| Tissue Specificity | Expressed primarily in kidney. Expressed in specific nephron segments and in the stria vascularis of the inner ear. |
| Post Translational Modifications | Palmitoylation is necessary for activation of plasma membrane-inserted CLC-K/barttin channels. |
| Function | Regulatory subunit of anion-selective CLCNKA:BSND and CLCNKB:BSND heteromeric channels involved in basolateral chloride conductance along the nephron to achieve urine concentration and maintain systemic acid-base homeostasis, and in the stria vascularis of the inner ear to establish the endocochlear potential necessary for normal hearing. Most likely acts as a chaperone that allosterically regulates proper sorting of CLCNKA:BSND and CLCNKB:BSND channels at the basolateral plasma membrane domain and functional switch to ion conducting state. Mediates constitutive opening of channel common gates. |
| Protein Name | Barttin |
| Database Links | Reactome: R-HSA-2672351 |
| Cellular Localisation | Basolateral Cell MembraneMulti-Pass Membrane ProteinMostly Sorted At The Basolateral MembraneA Significant Amount Also Observed IntracellularlyStaining In Membranes Of The Renal Tubule And Of Potassium-Secreting Epithelia Of The Inner Ear Is Basolateral |
| Alternative Protein Names | Barttin proteinBSND proteinBART protein |
Information sourced from Uniprot.org
