Human BRMS1 protein (Recombinant) (T7-Tag) (STJP018602)

SKU:
STJP018602
£134.50 - £738.50
Processing The item has been added
Enquire For Bulk Order

Covered by St John's Laboratory Guarantee

Host: E.coli
Applications: SDS-PAGE/Denatured
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Recombinant-Human BRMS1-T7-Tag protein was developed from e.coli and has a target region of T7-Tag. For use in research applications.
Formulation: Liquid in 20mM Tris-HCl buffer (pH 8.0) containing 10% Glycerol, 0.4M urea
Concentration: 0.25 mg/mL
Storage Instruction: For short term storage, keep at +2C to +8C for up to 1 week. For long term storage, aliquot and store at-20C, and avoid repeat freeze-thaw cycles.
Gene Symbol: BRMS1
Gene ID: 25855
Uniprot ID: BRMS1_HUMAN
Immunogen Region: 1-246aa
Accession Number: NP_056214.1
Immunogen: Human
Immunogen Sequence: MASMTGGQQM GRGSHMPVQP PSKDTEEMEA EGDSAAEMNG EEEESEEERS GSQTESEEES SEMDDEDYER RRSECVSEML DLEKQFSELK EKLFRERLSQ LRLRLEEVGA ERAPEYTEPL GGLQRSLKIR IQVAGIYKGF CLDVIRNKYE CELQGAKQHL ESEKLLLYDT LQGELQERIQ RLEEDRQSLD LSSEWWDDKL HARGSSRSWD SLPPSKRKKA PLVSGPYI
Tissue Specificity Expression levels are higher in term placentas than in early placentas. Low levels of expression observed in normal pregnancies and in molar pregnancies.
Post Translational Modifications Ubiquitinated by a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex containing SPOP, leading to proteasomal degradation.
Function Transcriptional repressor. Down-regulates transcription activation by NF-kappa-B by promoting the deacetylation of RELA at 'Lys-310'. Promotes HDAC1 binding to promoter regions. Down-regulates expression of anti-apoptotic genes that are controlled by NF-kappa-B. Promotes apoptosis in cells that have inadequate adherence to a substrate, a process called anoikis, and may thereby inhibit metastasis. May be a mediator of metastasis suppression in breast carcinoma.
Protein Name Breast Cancer Metastasis-Suppressor 1
Database Links Reactome: R-HSA-3214815
Reactome: R-HSA-9679191
Cellular Localisation Nucleus
Cytoplasm
Predominantly Nuclear
Alternative Protein Names Breast Cancer Metastasis-Suppressor 1 protein
BRMS1 protein

Information sourced from Uniprot.org

Related Products

Model Name Host Clonality Reactivity Application
STJP017413 Human RAB18 protein (Recombinant) (T7-Tag) (STJP017413) E.coli SDS-PAGE
STJP018740 Human ASAM protein (Recombinant) (T7-Tag) (STJP018740) E.coli SDS-PAGE/Denatured
STJP017532 Human ANAPC13 protein (Recombinant) (T7-Tag) (STJP017532) E.coli SDS-PAGE
STJP019752 Human RheB protein (Recombinant) (T7-Tag) (STJP019752) E.coli SDS-PAGE
STJP019077 Human Reg4 protein (Recombinant) (T7-Tag) (STJP019077) E.coli SDS-PAGE/Denatured

Related Products

!