Human BMPR2 (Bone Morphogenetic Protein Receptor Type-2) Antibody Pair (STJAP00182)

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STJAP00182-50
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Host: Mouse/Rabbit
Applications: ELISA
Reactivity: Human
Note: FOR SCIENTIFIC EDUCATIONAL RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR OTHER MEDICAL APPLICATIONS.
Short Description : This BMPR2 antibody pair contains complimentary capture and detection antibodies, which work together under the principals of the Sandwich ELISA.
Clonality : Monoclonal/Polyclonal
Conjugation: Unconjugated/Biotin
Formulation: Capture Buffer: PBS with 0.04% Proclin 300, 50% glycerol, pH 7.4.
Detection Buffer: PBS with 0.04% Proclin 300, 50% glycerol, pH 7.4.
Purification: Capture Purification: Protein A or G.
Detection Purification: Protein A & Antigen Affinity.
Concentration: 0.5 mg/mL
Storage Instruction: Store at-20°C for long term, and avoid freeze-thaw cycles.
Gene Symbol: BMPR2
Gene ID: 659
Uniprot ID: BMPR2_HUMAN
Immunogen: Capture immunogen: Recombinant Human BMPR2 protein.
Detection Immunogen: Recombinant Human BMPR2 protein.
Function On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Can also mediate signaling through the activation of the p38MAPK cascade. Binds to BMP7, BMP2 and, less efficiently, BMP4. Binding is weak but enhanced by the presence of type I receptors for BMPs. Mediates induction of adipogenesis by GDF6.
Protein Name Bone Morphogenetic Protein Receptor Type-2
Bmp Type-2 Receptor
Bmpr-2
Bone Morphogenetic Protein Receptor Type Ii
Bmp Type Ii Receptor
Bmpr-Ii
Database Links Reactome: R-HSA-201451
Cellular Localisation Cell Membrane
Single-Pass Type I Membrane Protein
Alternative Antibody Pair Names Bone Morphogenetic Protein Receptor Type-2 antibody pair
Bmp Type-2 Receptor antibody pair
Bmpr-2 antibody pair
Bone Morphogenetic Protein Receptor Type Ii antibody pair
Bmp Type Ii Receptor antibody pair
Bmpr-Ii antibody pair
BMPR2 antibody pair
PPH1 antibody pair

Information sourced from Uniprot.org

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