Human BIN2 protein (Recombinant) (N-His) (STJP006367)

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STJP006367
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Host: E. coli
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Recombinant-Human BIN2-N-His protein was developed from e. coli and has a target region of N-His. For use in research applications.
Formulation: Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Storage Instruction: Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt.
Gene Symbol: BIN2
Gene ID: 51411
Uniprot ID: BIN2_HUMAN
Immunogen Region: Met1-Asn244
Immunogen: Homo sapiens (Human)
Function Promotes cell motility and migration, probably via its interaction with the cell membrane and with podosome proteins that mediate interaction with the cytoskeleton. Modulates membrane curvature and mediates membrane tubulation. Plays a role in podosome formation. Inhibits phagocytosis.
Protein Name Bridging Integrator 2
Breast Cancer-Associated Protein 1
Database Links Reactome: R-HSA-6798695
Reactome: R-HSA-9673768
Cellular Localisation Cytoplasm
Cell Projection
Podosome Membrane
Peripheral Membrane Protein
Cytoplasmic Side
Cell Cortex
Phagocytic Cup
Associates With Membranes Enriched In Phosphoinositides
Detected In The Actin-Rich Cell Cortex At The Leading Edge Of Migrating Cells
Detected At Podosomes
At An Actin-Rich Ring-Like Structure
Alternative Protein Names Bridging Integrator 2 protein
Breast Cancer-Associated Protein 1 protein
BIN2 protein
BRAP1 protein

Information sourced from Uniprot.org

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