Human BIGH3/TGFBI protein (Recombinant) (No-Tag) (STJP019573)

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STJP019573
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Host: E.coli
Applications: SDS-PAGE
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Recombinant-Human BIGH3/TGFBI-No-Tag protein was developed from e.coli and has a target region of No-Tag. For use in research applications.
Formulation: Liquid in 20mM Tris-HCl buffer (pH 8.0)
Concentration: 1 mg/mL
Storage Instruction: For short term storage, keep at +2C to +8C for up to 1 week. For long term storage, aliquot and store at-20C, and avoid repeat freeze-thaw cycles.
Gene Symbol: TGFBI
Gene ID: 7045
Uniprot ID: BGH3_HUMAN
Immunogen Region: 502-636aa
Accession Number: NP_000349.1
Immunogen: Human
Immunogen Sequence: MGTVMDVLKG DNRFSMLVAA IQSAGLTETL NREGVYTVFA PTNEAFRALP PRERSRLLGD AKELANILKY HIGDEILVSG GIGALVRLKS LQGDKLEVSL KNNVVSVNKE PVAEPDIMAT NGVVHVITNV LQPPA
Tissue Specificity Highly expressed in the corneal epithelium. Expressed in heart, placenta, lung, liver, skeletal muscle, kidney and pancreas.
Post Translational Modifications Gamma-carboxylation is controversial. Gamma-carboxyglutamated.gamma-carboxyglutamate residues are formed by vitamin K dependent carboxylation.these residues may be required for binding to calcium. According to a more recent report, does not contain vitamin K-dependent gamma-carboxyglutamate residues. The EMI domain contains 2 expected intradomain disulfide bridges (Cys-49-Cys85 and Cys-84-Cys-97) and one unusual interdomain disulfide bridge to the second FAS1 domain (Cys-74-Cys-339). This arrangement violates the predicted disulfide bridge pattern of an EMI domain.
Function Plays a role in cell adhesion. May play a role in cell-collagen interactions.
Protein Name Transforming Growth Factor-Beta-Induced Protein Ig-H3
Beta Ig-H3
Kerato-Epithelin
Rgd-Containing Collagen-Associated Protein
Rgd-Cap
Database Links Reactome: R-HSA-977225
Cellular Localisation Secreted
Extracellular Space
Extracellular Matrix
May Be Associated Both With Microfibrils And With The Cell Surface
Alternative Protein Names Transforming Growth Factor-Beta-Induced Protein Ig-H3 protein
Beta Ig-H3 protein
Kerato-Epithelin protein
Rgd-Containing Collagen-Associated Protein protein
Rgd-Cap protein
TGFBI protein
BIGH3 protein

Information sourced from Uniprot.org

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