• Human BDNF protein (Active Recombinant) (C-His) (STJP001258)
  • Human BDNF protein (Active Recombinant) (C-His) (STJP001258)
  • Human BDNF protein (Active Recombinant) (C-His) (STJP001258)
  • Human BDNF protein (Active Recombinant) (C-His) (STJP001258)
  • Human BDNF protein (Active Recombinant) (C-His) (STJP001258)
  • Human BDNF protein (Active Recombinant) (C-His) (STJP001258)
  • Human BDNF protein (Active Recombinant) (C-His) (STJP001258)
  • Human BDNF protein (Active Recombinant) (C-His) (STJP001258)
  • Human BDNF protein (Active Recombinant) (C-His) (STJP001258)
  • Human BDNF protein (Active Recombinant) (C-His) (STJP001258)

Human BDNF protein (Active Recombinant) (C-His) (STJP001258)

SKU:
STJP001258

Current Stock:
Host: E. coli
Reactivity: Human
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Active Recombinant-Human BDNF-C-His protein was developed from e. coli and has a target region of C-His. For use in research applications.
Formulation: Lyophilized from a 0.22 Mu m filtered solution of PBS, pH 7.4. Contact us for customized product form or formulation.
Immunoreactivity: Measured by its binding ability in a functional ELISA. Immobilized Recombinant Human BDNF at 1 Mu g/mL (100 Mu L/well) can bind BDNF Rabbit mAb with a linear range of 0.4-2.15ng/mL.2. Measured by its binding ability in a functional ELISA. Immobilized
Gene Symbol: BDNF
Gene ID: 627
Uniprot ID: BDNF_HUMAN
Immunogen Region: His129-Arg247
Immunogen: Recombinant Human/Mouse/Rat BDNF Protein is produced by E. coli expression system. The target protein is expressed with sequence (His129-Arg247) of human BDNF (Accession #NP_733929.1.) fused with an initial Met at the N-terminus and a 6×His tag at th
Tissue Specificity Detected in blood plasma and in saliva (at protein level). Brain. Highly expressed in hippocampus, amygdala, cerebral cortex and cerebellum. Also expressed in heart, lung, skeletal muscle, testis, prostate and placenta.
Post Translational Modifications BDNF precursor form: N-glycosylated and glycosulfated, contrary to mature BDNF. Mature BDNF is produced by proteolytic removal of the propeptide, catalyzed by a FURIN family member. In addition, the precursor form is proteolytically cleaved within the propeptide, but this is not an obligatory intermediate for the production of mature BDNF. Can be converted into mature BDNF by plasmin (PLG).
Function Important signaling molecule that activates signaling cascades downstream of NTRK2. During development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS. The versatility of BDNF is emphasized by its contribution to a range of adaptive neuronal responses including long-term potentiation (LTP), long-term depression (LTD), certain forms of short-term synaptic plasticity, as well as homeostatic regulation of intrinsic neuronal excitability. BDNF precursor form: Important signaling molecule that activates signaling cascades downstream of NTRK2. Activates signaling cascades via the heterodimeric receptor formed by NGFR and SORCS2. Signaling via NGFR and SORCS2 plays a role in synaptic plasticity and long-term depression (LTD). Binding to NGFR and SORCS2 promotes neuronal apoptosis. Promotes neuronal growth cone collapse.
Protein Name Brain-Derived Neurotrophic Factor
Bdnf
Abrineurin Cleaved Into - Bdnf Precursor Form
Probdnf
Database Links Reactome: R-HSA-9022702
Reactome: R-HSA-9024909
Reactome: R-HSA-9026519
Reactome: R-HSA-9026527
Reactome: R-HSA-9028335
Reactome: R-HSA-9028731
Reactome: R-HSA-9032500
Reactome: R-HSA-9032759
Reactome: R-HSA-9032845
Reactome: R-HSA-9768919
Cellular Localisation Secreted
Bdnf Precursor Form: Secreted
A Proportion Of Bdnf Is Secreted As Immature Precursor (Probdnf)
Alternative Protein Names Brain-Derived Neurotrophic Factor protein
Bdnf protein
Abrineurin Cleaved Into - Bdnf Precursor Form protein
Probdnf protein
BDNF protein

Information sourced from Uniprot.org

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