| Host: |
HEK293 |
| Note: |
STRICTLY FOR FURTHER RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Recombinant-Human BCMA (CD269)-protein was developed from hek293. For use in research applications. |
| Conjugation: |
Unconjugated |
| Formulation: |
Lyophilised from 0.2 Mu m filtered mm Tris solution pH7.5. |
| Dilution Range: |
Spin the vial and reconstite in distilled water to a concentration not less than 0.1 mg/mL. This can then be diluted into other buffers. |
| Storage Instruction: |
Can be stored in working aliquots at°C-°C C for one month, or at-20°C C for six months, with a carrier protein without detectable loss of activity. Avoid repeated freeze/thaw cycles. NA |
| Endotoxin: |
Endotoxin content was assayed using a LAL gel clot method. Endotoxin level was found to be less than.1 ng/µg (1EU/µg). NA |
| Immunoreactivity: |
The ED (50) was determined by the ability to bind immobilized recombinant Human BAFF and was calculated to beng/ml. NA |
| Gene Symbol: |
TNFRSF17 |
| Gene ID: |
608 |
| Uniprot ID: |
TNR17_HUMAN |
| Immunogen Region: |
ECD |
| Immunogen: |
Optimized DNA sequence encoding Human BCMA extracellular domain sp|Q02223|1-54 fused to C terminal Human IgG1 Fc His tag was expressed in HEK293 Cells. NA |
| Immunogen Sequence: |
MLQMAGQCSQ NEYFDSLLHA CIPCQLRCSS NTPPLTCQRY CNASVTNSVK GTNA ILWTCL NA |
| Tissue Specificity | Expressed in mature B-cells, but not in T-cells or monocytes. |
| Function | Receptor for TNFSF13B/BLyS/BAFF and TNFSF13/APRIL. Promotes B-cell survival and plays a role in the regulation of humoral immunity. Activates NF-kappa-B and JNK. |
| Protein Name | Tumor Necrosis Factor Receptor Superfamily Member 17B-Cell Maturation ProteinCd Antigen Cd269 |
| Database Links | Reactome: R-HSA-5669034 |
| Cellular Localisation | Cell MembraneSingle-Pass Type Iii Membrane ProteinEndomembrane SystemPerinuclear Golgi-Like Structures |
| Alternative Protein Names | Tumor Necrosis Factor Receptor Superfamily Member 17 proteinB-Cell Maturation Protein proteinCd Antigen Cd269 proteinTNFRSF17 proteinBCM proteinBCMA protein |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
