| Tissue Specificity | Expressed at high levels in testis and skeletal muscle and at lower levels in brain, heart, kidney, liver, lung, ovary, pancreas, placenta, and spleen. |
| Function | During interphase, required for microtubule organizing and anchoring activities. During mitosis, required for the organization and stabilization of the spindle pole. Isoform 2/alpha is particularly important for the regulation of microtubule anchoring, microtubule stability, spindle architecture and spindle orientation, compared to isoform 1/beta. May promote cell cycle arrest by enhancing the inhibition of CDK2 activity by CDKN1A. May be required for repair of DNA damage by homologous recombination in conjunction with BRCA2. May not be involved in non-homologous end joining (NHEJ). |
| Protein Name | Brca2 And Cdkn1a-Interacting ProteinP21- And Cdk-Associated Protein 1Protein Tok-1 |
| Database Links | |
| Cellular Localisation | NucleusCytoplasmCytoskeletonMicrotubule Organizing CenterCentrosomeCentrioleSpindle PoleColocalizes With Brca2 In Discrete Nuclear FociIn InterphasePreferential Localizes To The Mother CentrioleRecruited To The Spindle Pole Matrix And Centrosome By Microtubules And Dynein/Dynactin ActivityIsoform 1: CytoplasmIsoform 1/Beta Tends To Be Less Abundant AtAnd Less Strongly Associated WithCentrosomes Than Isoform 2/AlphaIsoform 2: CytoplasmIsoform 2/Alpha Tends To Be More Abundant AtAnd More Strongly Associated WithCentrosomes Than Isoform 1/Beta |
| Alternative Protein Names | Brca2 And Cdkn1a-Interacting Protein proteinP21- And Cdk-Associated Protein 1 proteinProtein Tok-1 proteinBCCIP proteinTOK1 protein |
Information sourced from Uniprot.org
