| Function | Regulatory subunit of the ATP-dependent ACF-1 and ACF-5 ISWI chromatin remodeling complexes, which form ordered nucleosome arrays on chromatin and slide edge- and center-positioned histone octamers away from their original location on the DNA template to facilitate access to DNA during DNA-templated processes such as DNA replication, transcription, and repair. Both complexes regulate the spacing of nucleosomes along the chromatin and have the ability to slide mononucleosomes to the center of a DNA template in an ATP-dependent manner. The ACF-1 ISWI chromatin remodeling complex has a lower ATP hydrolysis rate than the ACF-5 ISWI chromatin remodeling complex. Has a role in sensing the length of DNA which flank nucleosomes, which modulates the nucleosome spacing activity of the ACF-5 ISWI chromatin remodeling complex. Involved in DNA replication and together with SMARCA5/SNF2H is required for replication of pericentric heterochromatin in S-phase. May have a role in nuclear receptor-mediated transcription repression. |
| Protein Name | Bromodomain Adjacent To Zinc Finger Domain Protein 1aAtp-Dependent Chromatin-Remodeling ProteinAtp-Utilizing Chromatin Assembly And Remodeling Factor 1Hacf1Chrac Subunit Acf1Williams Syndrome Transcription Factor-Related Chromatin-Remodeling Factor 180Wcrf180Hwalp1 |
| Database Links | |
| Cellular Localisation | NucleusLocalizes To Pericentric HeterochromatinMay Target The Chrac Complex To HeterochromatinLocalizes To Sites Of Dna Damage |
| Alternative Protein Names | Bromodomain Adjacent To Zinc Finger Domain Protein 1a proteinAtp-Dependent Chromatin-Remodeling Protein proteinAtp-Utilizing Chromatin Assembly And Remodeling Factor 1 proteinHacf1 proteinChrac Subunit Acf1 proteinWilliams Syndrome Transcription Factor-Related Chromatin-Remodeling Factor 180 proteinWcrf180 proteinHwalp1 proteinBAZ1A proteinACF1 proteinWCRF180 proteinHSPC317 protein |
Information sourced from Uniprot.org
