Human B7-H7/HHLA2 protein (Recombinant) (C-hFc) (STJP020257)

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STJP020257-100
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Covered by St John's Laboratory Guarantee

Host: HEK293 cells
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Conjugation: Unconjugated
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Determination Method: < 1 EU/Mu g of the protein by LAL method.
Gene Symbol: HHLA2
Gene ID: 11148
Uniprot ID: HHLA2_HUMAN
Immunogen Region: Ile23-Asn344
Immunogen: Recombinant Human B7-H7/HHLA2 Protein is expressed from Expi293 with hFc tag at the C-terminal.；It contains Ile23-Asn344.
Immunogen Sequence: IFPLAFFIYVPMNEQIVIGR LDEDIILPSSFERGSEVVIH WKYQDSYKVHSYYKGSDHLE SQDPRYANRTSLFYNEIQNG NASLFFRRVSLLDEGIYTCY VGTAIQVITNKVVLKVGVFL TPVMKYEKRNTNSFLICSVL SVYPRPIITWKMDNTPISEN NMEETGSLDSFSINSPLNIT GSNSSYECTIENSLLKQTWT GRWTMKDGLHKMQSEHVSLS CQPVNDYFSPNQDFKVTWS
Tissue Specificity Expressed at high levels in colon, kidney, testis, lung and pancreas, and at lower levels in small intestine, liver and skeletal muscle. In immune cells, highly expressed in B-cells, dendritic cells and macrophages. Not detected in T-cells.
Function Through interaction with TMIGD2, costimulates T-cells in the context of TCR-mediated activation. Enhances T-cell proliferation and cytokine production via an AKT-dependent signaling cascade.
Protein Name Herv-H Ltr-Associating Protein 2
Human Endogenous Retrovirus-H Long Terminal Repeat-Associating Protein 2
Database Links
Cellular Localisation Membrane
Single-Pass Type I Membrane Protein
Alternative Protein Names Herv-H Ltr-Associating Protein 2 protein
Human Endogenous Retrovirus-H Long Terminal Repeat-Associating Protein 2 protein
HHLA2 protein

Information sourced from Uniprot.org

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