Human B7-H5/Gi24/VISTA protein (Recombinant) (C-hFc&His) (STJP001100)

SKU:

STJP001100

£59.50 - £223.50

Host:	HEK293 cells
Reactivity:	Human
Note:	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description:	Recombinant-Human B7-H5/Gi24/VISTA-C-hFc&His protein was developed from hek293 cells and has a target region of C-hFc&His. For use in research applications.

Formulation:

Lyophilized from a 0.22 Mu m filtered solution of PBS, pH 7.4. Contact us for customized product form or formulation.

Gene Symbol:	VSIR
Gene ID:	64115
Uniprot ID:	VISTA_HUMAN
Immunogen:	Recombinant Human B7-H5/Gi24/VISTA Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (Phe33-Ala194) of human VISTA/B7-H5/PD-1H (Accession #AAH20568.1) fused with an Fc, 6×His tag at the C-terminus.

Tissue Specificity	Expressed in spleen. Detected on a number of myeloid cells including CD11b monocytes, CD66b+ neutrophils, at low levels on CD4+ and CD8+ T-cells, and in a subset of NK cells. Not detected on B cells (at protein level). Expressed at high levels in placenta, spleen, plasma blood leukocytes, and lung. Expressed at moderate levels in lymph node, bone marrow, fat, uterus, and trachea. Has low expression levels in other tissues.
Post Translational Modifications	At the cell surface, may be cleaved by MMP14. N-glycosylated.
Function	Immunoregulatory receptor which inhibits the T-cell response. May promote differentiation of embryonic stem cells, by inhibiting BMP4 signaling. May stimulate MMP14-mediated MMP2 activation.
Protein Name	V-Type Immunoglobulin Domain-Containing Suppressor Of T-Cell Activation Platelet Receptor Gi24 Stress-Induced Secreted Protein-1 Sisp-1 V-Set Domain-Containing Immunoregulatory Receptor V-Set Immunoregulatory Receptor
Cellular Localisation	Cell Membrane Single-Pass Type I Membrane Protein
Alternative Protein Names	V-Type Immunoglobulin Domain-Containing Suppressor Of T-Cell Activation protein Platelet Receptor Gi24 protein Stress-Induced Secreted Protein-1 protein Sisp-1 protein V-Set Domain-Containing Immunoregulatory Receptor protein V-Set Immunoregulatory Receptor protein VSIR protein C10orf54 protein SISP1 protein VISTA protein PP2135 protein UNQ730 protein PRO1412 protein

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance