Mouse B7-H5/Gi24/VISTA protein (Recombinant) (C-His) (STJP001321)
SPECIFICATIONS
HostHEK293 cells
ConjugationUnconjugated
ImmunogenRecombinant Mouse B7-H5/Gi24/VISTA Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (Phe33-Ala191) of Mouse VISTA (Accession #NP_083008.1) fused with an 6×His tag at the C-terminus.
General Information
| Short Description | Recombinant-Mouse B7-H5/Gi24/VISTA-C-His protein was developed in hek293 cells using the region Phe33-Ala191. For use in research applications. |
| Host | HEK293 cells |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Conjugation | Unconjugated |
| Formulation | Lyophilised from a 0.22 Mu m filtered solution of PBS, pH 7.4. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Immunoreactivity | Measured by its binding ability in a functional ELISA.Immobilized Mouse B7-H5/VISTA at 0.5 Mu g/mL (100 Mu L/well) can bind B7-H5/VISTA Rabbit pAb with a linear range of 0.01-2.6 ng/mL. |
| Determination Method | < 0.1 EU/Mu g of the protein by LAL method. |
Target Information
| Gene Symbol | Vsir |
| Gene ID | 74048 |
| Uniprot ID | VISTA_MOUSE |
| Immunogen | Recombinant Mouse B7-H5/Gi24/VISTA Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (Phe33-Ala191) of Mouse VISTA (Accession #NP_083008.1) fused with an 6×His tag at the C-terminus. |
| Immunogen Region | Phe33-Ala191 |
| Immunogen Sequence | FKVTTPYSLYVCPEGQNATL TCRILGPVSKGHDVTIYKTW YLSSRGEVQMCKEHRPIRNF TLQHLQHHGSHLKANASHD QPQKHGLELASDHHGNFSIT LRNVTPRDSGLYCCLVIELK N HHPEQRFYGSMELQVQAG KGSGSTCMASNEQDSDSITA A |
Additional Info
| Post Translational Modifications | At the cell surface, may be cleaved by MMP14. N-glycosylated. |
| Function | Immunoregulatory receptor which inhibits the T-cell response. May promote differentiation of embryonic stem cells, by inhibiting BMP4 signaling. May stimulate MMP14-mediated MMP2 activation. |
| Protein Name | V-Type Immunoglobulin Domain-Containing Suppressor Of T-Cell ActivationPlatelet Receptor Gi24V-Set Domain-Containing Immunoregulatory ReceptorV-Set Immunoregulatory Receptor |
| Database Links | |
| Cellular Localisation | Cell MembraneSingle-Pass Type I Membrane Protein |
| Alternative Protein Names | V-Type Immunoglobulin Domain-Containing Suppressor Of T-Cell Activation proteinPlatelet Receptor Gi24 proteinV-Set Domain-Containing Immunoregulatory Receptor proteinV-Set Immunoregulatory Receptor proteinVsir proteinDies1 proteinPD-1H proteinVISTA protein |
Information sourced from Uniprot.org