| Host: | HEK293 |
| Note: | STRICTLY FOR FURTHER RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: | Recombinant-Human B7-H3 (4Ig) /B7-H3b-C-His-Avi protein was developed from hek293 and has a target region of C-His-Avi. For use in research applications. |
| Conjugation: | Biotin |
| Formulation: | Lyophilised from 0.2 µm filtered PBS solution pH7.4. |
| Dilution Range: | Upon receipt centrifuge vial to ensure maximal product extraction, recommended: 20sec, 5K RPM |
| Storage Instruction: | The lyophilized protein is stable for at least 1 year from date of receipt at-20°C. |
| Endotoxin: | Endotoxin content was assayed using a LAL gel clot method. Endotoxin level was found to be less than 0.1 ng/µg (1EU/µg). |
| Gene Symbol: | CD276 |
| Gene ID: | 80381 |
| Uniprot ID: | CD276_HUMAN |
| Immunogen Region: | Gly27-Thr461 |
| Immunogen: | DNA sequence encoding Human B7-H3 (4Ig) /B7-H3b including a C-His-Avi tag was expressed in HEK293 Cells. The recombinant protein was then biotinylated site specific using the AVItag biotinylation technology. |
| Function | May participate in the regulation of T-cell-mediated immune response. May play a protective role in tumor cells by inhibiting natural-killer mediated cell lysis as well as a role of marker for detection of neuroblastoma cells. May be involved in the development of acute and chronic transplant rejection and in the regulation of lymphocytic activity at mucosal surfaces. Could also play a key role in providing the placenta and fetus with a suitable immunological environment throughout pregnancy. Both isoform 1 and isoform 2 appear to be redundant in their ability to modulate CD4 T-cell responses. Isoform 2 is shown to enhance the induction of cytotoxic T-cells and selectively stimulates interferon gamma production in the presence of T-cell receptor signaling. |
| Protein Name | Cd276 Antigen 4ig-B7-H3 B7 Homolog 3 B7-H3 Costimulatory Molecule Cd Antigen Cd276 |
| Cellular Localisation | Membrane Single-Pass Type I Membrane Protein |
| Alternative Protein Names | Cd276 Antigen protein 4ig-B7-H3 protein B7 Homolog 3 protein B7-H3 protein Costimulatory Molecule protein Cd Antigen Cd276 protein CD276 protein B7H3 protein PSEC0249 protein UNQ309 protein PRO352 protein |
Information sourced from Uniprot.org
