• Biotinylated Human B7-H3 (4Ig) on Tris-Bis PAGE under reduced condition. The purity is greater than 95%.
  • The purity of Biotinylated Human B7-H3 (4Ig) is greater than 95% as determined by SEC-HPLC.
  • Immobilized Anti-B7-H3 Antibody, hFc Tag at 0. 5 Mu g/ml (100 Mu l/well) on the plate. Dose response curve for Biotinylated Human B7-H3 (4Ig) , His Tag with the EC50 of 7. 7ng/ml determined by ELISA.

Human B7-H3 (4Ig) /B7-H3b protein (Recombinant) (C-His-Avi) {Biotin} (STJP001744)

SKU:
STJP001744

$806.63 - $2,483.33
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Host: HEK293
Note: STRICTLY FOR FURTHER RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Recombinant-Human B7-H3 (4Ig) /B7-H3b-C-His-Avi protein was developed from hek293 and has a target region of C-His-Avi. For use in research applications.
Conjugation: Biotin
Formulation: Lyophilised from 0.2 µm filtered PBS solution pH7.4.
Dilution Range: Upon receipt centrifuge vial to ensure maximal product extraction, recommended: 20sec, 5K RPM
Storage Instruction: The lyophilized protein is stable for at least 1 year from date of receipt at-20°C.
Endotoxin: Endotoxin content was assayed using a LAL gel clot method. Endotoxin level was found to be less than 0.1 ng/µg (1EU/µg).
Gene Symbol: CD276
Gene ID: 80381
Uniprot ID: CD276_HUMAN
Immunogen Region: Gly27-Thr461
Immunogen: DNA sequence encoding Human B7-H3 (4Ig) /B7-H3b including a C-His-Avi tag was expressed in HEK293 Cells. The recombinant protein was then biotinylated site specific using the AVItag biotinylation technology.
Function May participate in the regulation of T-cell-mediated immune response. May play a protective role in tumor cells by inhibiting natural-killer mediated cell lysis as well as a role of marker for detection of neuroblastoma cells. May be involved in the development of acute and chronic transplant rejection and in the regulation of lymphocytic activity at mucosal surfaces. Could also play a key role in providing the placenta and fetus with a suitable immunological environment throughout pregnancy. Both isoform 1 and isoform 2 appear to be redundant in their ability to modulate CD4 T-cell responses. Isoform 2 is shown to enhance the induction of cytotoxic T-cells and selectively stimulates interferon gamma production in the presence of T-cell receptor signaling.
Protein Name Cd276 Antigen
4ig-B7-H3
B7 Homolog 3
B7-H3
Costimulatory Molecule
Cd Antigen Cd276
Cellular Localisation Membrane
Single-Pass Type I Membrane Protein
Alternative Protein Names Cd276 Antigen protein
4ig-B7-H3 protein
B7 Homolog 3 protein
B7-H3 protein
Costimulatory Molecule protein
Cd Antigen Cd276 protein
CD276 protein
B7H3 protein
PSEC0249 protein
UNQ309 protein
PRO352 protein

Information sourced from Uniprot.org

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