Human AUP1 protein (Recombinant) (N-His) (STJP006289)

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STJP006289
€410.63 - €1,796.88
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Host: E. coli
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Recombinant-Human AUP1-N-His protein was developed from e. coli and has a target region of N-His. For use in research applications.
Formulation: Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Storage Instruction: Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt.
Gene Symbol: AUP1
Gene ID: 550
Uniprot ID: AUP1_HUMAN
Immunogen Region: Val201-Asp410
Immunogen: Homo sapiens (Human)
Post Translational Modifications Monoubiquitinated and diubiquitinated. (Microbial infection) Not ubiquitinated following Dengue virus infection.
Function Plays a role in the translocation of terminally misfolded proteins from the endoplasmic reticulum lumen to the cytoplasm and their degradation by the proteasome. Plays a role in lipid droplet formation. Induces lipid droplet clustering. Recruits ubiquitin-conjugating enzyme UBE2G2 to lipid droplets which facilitates its interaction with ubiquitin ligases AMFR/gp78 and RNF139/TRC8, leading to sterol-induced ubiquitination of HMGCR and its subsequent proteasomal degradation. Also required for the degradation of INSIG1, SREBF1 and SREBF2. Plays a role in regulating assembly and secretion of very low density lipoprotein particles and stability of apolipoprotein APOB. (Microbial infection) Following Dengue virus infection, required for induction of lipophagy which facilitates production of virus progeny particles.
Protein Name Lipid Droplet-Regulating Vldl Assembly Factor Aup1
Ancient Ubiquitous Protein 1
Cellular Localisation Endoplasmic Reticulum Membrane
Peripheral Membrane Protein
Lipid Droplet
Cytoplasmic Vesicle
Autophagosome
(Microbial Infection) Upon Dengue Virus Infection
Relocates From Lipid Droplets To Autophagosomes
Alternative Protein Names Lipid Droplet-Regulating Vldl Assembly Factor Aup1 protein
Ancient Ubiquitous Protein 1 protein
AUP1 protein

Information sourced from Uniprot.org

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