Human AUP1 protein (Recombinant) (N-His) (STJP006289)
SPECIFICATIONS
HostE.coli
ImmunogenHomo sapiens (Human)
General Information
| Short Description | Recombinant-Human AUP1-N-His protein was developed from e.coli for the region N-His. For use in research applications. |
| Applications | ELISA/Immunogen/SDS-PAGE/WB |
| Host | E.coli |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Dilution Range | Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details. |
| Formulation | Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol. |
| Storage Instruction | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt. |
Target Information
| Gene Symbol | AUP1 |
| Gene ID | 550 |
| Uniprot ID | AUP1_HUMAN |
| Immunogen | Homo sapiens (Human) |
| Immunogen Region | Val201-Asp410 |
Additional Info
| Post Translational Modifications | Monoubiquitinated and diubiquitinated. (Microbial infection) Not ubiquitinated following Dengue virus infection. |
| Function | Plays a role in the translocation of terminally misfolded proteins from the endoplasmic reticulum lumen to the cytoplasm and their degradation by the proteasome. Plays a role in lipid droplet formation. Induces lipid droplet clustering. Recruits ubiquitin-conjugating enzyme UBE2G2 to lipid droplets which facilitates its interaction with ubiquitin ligases AMFR/gp78 and RNF139/TRC8, leading to sterol-induced ubiquitination of HMGCR and its subsequent proteasomal degradation. Also required for the degradation of INSIG1, SREBF1 and SREBF2. Plays a role in regulating assembly and secretion of very low density lipoprotein particles and stability of apolipoprotein APOB. (Microbial infection) Following Dengue virus infection, required for induction of lipophagy which facilitates production of virus progeny particles. |
| Protein Name | Lipid Droplet-Regulating Vldl Assembly Factor Aup1Ancient Ubiquitous Protein 1 |
| Database Links | |
| Cellular Localisation | Endoplasmic Reticulum MembranePeripheral Membrane ProteinLipid DropletCytoplasmic VesicleAutophagosome(Microbial Infection) Upon Dengue Virus InfectionRelocates From Lipid Droplets To Autophagosomes |
| Alternative Protein Names | Lipid Droplet-Regulating Vldl Assembly Factor Aup1 proteinAncient Ubiquitous Protein 1 proteinAUP1 protein |
Information sourced from Uniprot.org