Human ATP6AP2 protein (Recombinant) (N-His) (STJP006549)

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STJP006549
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Host: E. coli
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Recombinant-Human ATP6AP2-N-His protein was developed from e. coli and has a target region of N-His. For use in research applications.
Formulation: Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Storage Instruction: Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt.
Gene Symbol: ATP6AP2
Gene ID: 10159
Uniprot ID: RENR_HUMAN
Immunogen Region: Asn17-Glu302
Immunogen: Homo sapiens (Human)
Post Translational Modifications Phosphorylated. Proteolytically cleaved by a furin-like convertase in the trans-Golgi network to generate N- and C-terminal fragments.
Function Multifunctional protein which functions as a renin, prorenin cellular receptor and is involved in the assembly of the lysosomal proton-transporting V-type ATPase (V-ATPase) and the acidification of the endo-lysosomal system. May mediate renin-dependent cellular responses by activating ERK1 and ERK2. By increasing the catalytic efficiency of renin in AGT/angiotensinogen conversion to angiotensin I, may also play a role in the renin-angiotensin system (RAS). Through its function in V-type ATPase (v-ATPase) assembly and acidification of the lysosome it regulates protein degradation and may control different signaling pathways important for proper brain development, synapse morphology and synaptic transmission.
Protein Name Renin Receptor
Atpase H(+-Transporting Lysosomal Accessory Protein 2
Atpase H(+-Transporting Lysosomal-Interacting Protein 2
Er-Localized Type I Transmembrane Adapter
Embryonic Liver Differentiation Factor 10
N14f
Renin/Prorenin Receptor
Vacuolar Atp Synthase Membrane Sector-Associated Protein M8-9
Atp6m8-9
V-Atpase M8.9 Subunit Cleaved Into - Renin Receptor N-Terminal Fragment - Renin Receptor C-Terminal Fragment
Database Links Reactome: R-HSA-2022377
Reactome: R-HSA-6798695
Cellular Localisation Endoplasmic Reticulum Membrane
Single-Pass Type I Membrane Protein
Lysosome Membrane
Cytoplasmic Vesicle
Autophagosome Membrane
Cell Projection
Dendritic Spine Membrane
Axon
Endosome Membrane
Clathrin-Coated Vesicle Membrane
Secretory Vesicle
Synaptic Vesicle Membrane
Alternative Protein Names Renin Receptor protein
Atpase H(+-Transporting Lysosomal Accessory Protein 2 protein
Atpase H(+-Transporting Lysosomal-Interacting Protein 2 protein
Er-Localized Type I Transmembrane Adapter protein
Embryonic Liver Differentiation Factor 10 protein
N14f protein
Renin/Prorenin Receptor protein
Vacuolar Atp Synthase Membrane Sector-Associated Protein M8-9 protein
Atp6m8-9 protein
V-Atpase M8.9 Subunit Cleaved Into - Renin Receptor N-Terminal Fragment - Renin Receptor C-Terminal Fragment protein
ATP6AP2 protein
ATP6IP2 protein
CAPER protein
ELDF10 protein
HT028 protein
MSTP009 protein
PSEC0072 protein

Information sourced from Uniprot.org

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