Human ATP6AP2 protein (Recombinant) (N-His) (STJP006549)
SPECIFICATIONS
HostE.coli
ImmunogenHomo sapiens (Human)
General Information
| Short Description | Recombinant-Human ATP6AP2-N-His protein was developed from e.coli for the region N-His. For use in research applications. |
| Applications | ELISA/Immunogen/SDS-PAGE/WB |
| Host | E.coli |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Dilution Range | Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details. |
| Formulation | Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol. |
| Storage Instruction | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt. |
Target Information
| Gene Symbol | ATP6AP2 |
| Gene ID | 10159 |
| Uniprot ID | RENR_HUMAN |
| Immunogen | Homo sapiens (Human) |
| Immunogen Region | Asn17-Glu302 |
Additional Info
| Post Translational Modifications | Phosphorylated. Proteolytically cleaved by a furin-like convertase in the trans-Golgi network to generate N- and C-terminal fragments. |
| Function | Multifunctional protein which functions as a renin, prorenin cellular receptor and is involved in the assembly of the lysosomal proton-transporting V-type ATPase (V-ATPase) and the acidification of the endo-lysosomal system. May mediate renin-dependent cellular responses by activating ERK1 and ERK2. By increasing the catalytic efficiency of renin in AGT/angiotensinogen conversion to angiotensin I, may also play a role in the renin-angiotensin system (RAS). Through its function in V-type ATPase (v-ATPase) assembly and acidification of the lysosome it regulates protein degradation and may control different signaling pathways important for proper brain development, synapse morphology and synaptic transmission. |
| Protein Name | Renin ReceptorAtpase H(+-Transporting Lysosomal Accessory Protein 2Atpase H(+-Transporting Lysosomal-Interacting Protein 2Er-Localized Type I Transmembrane AdapterEmbryonic Liver Differentiation Factor 10N14fRenin/Prorenin ReceptorVacuolar Atp Synthase Membrane Sector-Associated Protein M8-9Atp6m8-9V-Atpase M8.9 Subunit Cleaved Into - Renin Receptor N-Terminal Fragment - Renin Receptor C-Terminal Fragment |
| Database Links | Reactome: R-HSA-2022377Reactome: R-HSA-6798695 |
| Cellular Localisation | Endoplasmic Reticulum MembraneSingle-Pass Type I Membrane ProteinLysosome MembraneCytoplasmic VesicleAutophagosome MembraneCell ProjectionDendritic Spine MembraneAxonEndosome MembraneClathrin-Coated Vesicle MembraneSecretory VesicleSynaptic Vesicle Membrane |
| Alternative Protein Names | Renin Receptor proteinAtpase H(+-Transporting Lysosomal Accessory Protein 2 proteinAtpase H(+-Transporting Lysosomal-Interacting Protein 2 proteinEr-Localized Type I Transmembrane Adapter proteinEmbryonic Liver Differentiation Factor 10 proteinN14f proteinRenin/Prorenin Receptor proteinVacuolar Atp Synthase Membrane Sector-Associated Protein M8-9 proteinAtp6m8-9 proteinV-Atpase M8.9 Subunit Cleaved Into - Renin Receptor N-Terminal Fragment - Renin Receptor C-Terminal Fragment proteinATP6AP2 proteinATP6IP2 proteinCAPER proteinELDF10 proteinHT028 proteinMSTP009 proteinPSEC0072 protein |
Information sourced from Uniprot.org