| Function | Required for both basal and inducible autophagy. Determines the localization of the autophagy-specific PI3-kinase complex PI3KC3-C1. Plays a role in autophagosome formation and MAP1LC3/LC3 conjugation to phosphatidylethanolamine. Promotes BECN1 translocation from the trans-Golgi network to autophagosomes. Enhances PIK3C3 activity in a BECN1-dependent manner. Essential for the autophagy-dependent phosphorylation of BECN1. Stimulates the phosphorylation of BECN1, but suppresses the phosphorylation PIK3C3 by AMPK. Binds to STX17-SNAP29 binary t-SNARE complex on autophagosomes and primes it for VAMP8 interaction to promote autophagosome-endolysosome fusion. Modulates the hepatic lipid metabolism. |
| Protein Name | Beclin 1-Associated Autophagy-Related Key RegulatorBarkorAutophagy-Related Protein 14-Like ProteinAtg14l |
| Database Links | Reactome: R-HSA-1632852Reactome: R-HSA-9705671Reactome: R-HSA-983170 |
| Cellular Localisation | CytoplasmEndoplasmic Reticulum MembranePeripheral Membrane ProteinPreautophagosomal Structure MembraneCytoplasmic VesicleAutophagosome MembraneCytosolic Under Nutrient-Rich ConditionsFollowing Autophagy StimuliSuch As Starvation Or Rapamycin InductionPredominantly Detected In Cytoplasmic FociIdentified As Isolation Membranes And AutophagosomesAccumulates On Highly Curved Ptdins(3)P Enriched Autophagic Membrane Via Its Bats Domain To Sense And Maintain Membrane CurvatureLocalizes Also To Discrete Punctae Along The Ciliary Axoneme And To The Base Of The Ciliary Axoneme |
| Alternative Protein Names | Beclin 1-Associated Autophagy-Related Key Regulator proteinBarkor proteinAutophagy-Related Protein 14-Like Protein proteinAtg14l proteinATG14 proteinATG14L proteinKIAA0831 protein |
Information sourced from Uniprot.org
