Human ARHGEF12 protein (Recombinant) (N-His) (STJP015196)

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STJP015196
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Host: E.coli
Applications: ELISA/Immunogen/SDS-PAGE/WB
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Recombinant-Human ARHGEF12-N-His protein was developed from e.coli and has a target region of N-His. For use in research applications.
Formulation: Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Dilution Range: Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Storage Instruction: Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt.
Endotoxin: Please contact us for further information.
Gene Symbol: ARHGEF12
Gene ID: 23365
Uniprot ID: ARHGC_HUMAN
Immunogen Region: Asn366-Gly556
Immunogen: Homo sapiens (Human)
Function May play a role in the regulation of RhoA GTPase by guanine nucleotide-binding alpha-12 (GNA12) and alpha-13 (GNA13). Acts as guanine nucleotide exchange factor (GEF) for RhoA GTPase and may act as GTPase-activating protein (GAP) for GNA12 and GNA13.
Protein Name Rho Guanine Nucleotide Exchange Factor 12
Leukemia-Associated Rhogef
Database Links Reactome: R-HSA-193648
Reactome: R-HSA-416482
Reactome: R-HSA-416572
Reactome: R-HSA-8980692
Reactome: R-HSA-9013026
Reactome: R-HSA-9013106
Reactome: R-HSA-9013148
Cellular Localisation Cytoplasm
Membrane
Translocated To The Membrane Upon Stimulation
Alternative Protein Names Rho Guanine Nucleotide Exchange Factor 12 protein
Leukemia-Associated Rhogef protein
ARHGEF12 protein
KIAA0382 protein
LARG protein

Information sourced from Uniprot.org