| Host: | HEK293 cells |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Formulation: | Lyophilised from a 0.22 Mu m filtered solution of PBS, pH 7.4. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Determination Method: | <0.1 EU/Mu g |
| Gene Symbol: | APOH |
| Gene ID: | 350 |
| Uniprot ID: | APOH_HUMAN |
| Immunogen: | Recombinant Human Apolipoprotein H/ApoH Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (Gly20-Cys345) of human APOH (Accession #NP_000033.2) fused with a 6×His tag at the C-terminus. |
| Immunogen Sequence: | GRTCPKPDDLPFSTVVPLKT FYEPGEEITYSCKPGYVSRG GMRKFICPLTGLWPINTLKC TPRVCPFAGILENGAVRYTT FEYPNTISFSCNTGFYLNGA DSAKCTEEGKWSPELPVCAP IICPPPSIPTFATLRVYKPS AGNNSLYRDTAVFECLPQHA MFGNDTITCTTHGNWTKLPE CREVKCPFPSRPDNGFVNYP AKPTLYYKDKATFGCHDGYS LDGPEEIECTKLGNWSAMP |
| Post Translational Modifications | N- and O-glycosylated. PubMed:6587378 also reports glycosylation on 'Asn-188' for their allele. |
| Function | Binds to various kinds of negatively charged substances such as heparin, phospholipids, and dextran sulfate. May prevent activation of the intrinsic blood coagulation cascade by binding to phospholipids on the surface of damaged cells. |
| Protein Name | Beta-2-Glycoprotein 1Apc InhibitorActivated Protein C-Binding ProteinAnticardiolipin CofactorApolipoprotein HApo-HBeta-2-Glycoprotein IB2gpiBeta(2gpi |
| Database Links | Reactome: R-HSA-114608 |
| Cellular Localisation | Secreted |
| Alternative Protein Names | Beta-2-Glycoprotein 1 proteinApc Inhibitor proteinActivated Protein C-Binding Protein proteinAnticardiolipin Cofactor proteinApolipoprotein H proteinApo-H proteinBeta-2-Glycoprotein I proteinB2gpi proteinBeta(2gpi proteinAPOH proteinB2G1 protein |
Information sourced from Uniprot.org