| Post Translational Modifications | Topaquinone (TPQ) is generated by copper-dependent autoxidation of a specific tyrosyl residue. N- and O-glycosylated. |
| Function | Catalyzes the oxidative deamination of primary amines to the corresponding aldehydes with the concomitant production of hydrogen peroxide and ammonia. Has a preference for the primary monoamines methylamine and benzylamine. Could also act on 2-phenylethylamine but much less efficiently. At endothelial cells surface can also function as a cell adhesion protein that participates in lymphocyte extravasation and recirculation by mediating the binding of lymphocytes to peripheral lymph node vascular endothelial cells in an L-selectin-independent fashion. Isoform 2: Has no semicarbazide-sensitive amine oxidase (SSAO) activity. |
| Protein Name | Amine Oxidase Copper-Containing 3Amine Oxidase Copper-Containing 3Copper Amine OxidaseHpaoSemicarbazide-Sensitive Amine OxidaseSsaoVascular Adhesion Protein 1Vap-1 |
| Database Links | Reactome: R-HSA-211945 |
| Cellular Localisation | Cell MembraneSingle-Pass Type Ii Membrane Protein |
| Alternative Protein Names | Amine Oxidase Copper-Containing 3 proteinAmine Oxidase Copper-Containing 3 proteinCopper Amine Oxidase proteinHpao proteinSemicarbazide-Sensitive Amine Oxidase proteinSsao proteinVascular Adhesion Protein 1 proteinVap-1 proteinAOC3 proteinVAP1 protein |
Information sourced from Uniprot.org
