Human Annexin A2/ANXA2 protein (Recombinant) (N-His) (STJP020327)

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STJP020327-100
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Host: E.coli
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Conjugation: Unconjugated
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Determination Method: < 1 EU/Mu g of the protein by LAL method.
Gene Symbol: ANXA2
Gene ID: 302
Uniprot ID: ANXA2_HUMAN
Immunogen Region: Ser2-Asp339
Immunogen: Recombinant Human Annexin A2/ANXA2 Protein is produced by E. coli expression system. The target protein is expressed with sequence Ser2-Asp339. of Human Annexin A2/ANXA2 (Accession #) fused with His tag at the N-terminal
Post Translational Modifications Phosphorylation of Tyr-24 enhances heat stress-induced translocation to the cell surface. ISGylated.
Function Calcium-regulated membrane-binding protein whose affinity for calcium is greatly enhanced by anionic phospholipids. It binds two calcium ions with high affinity. May be involved in heat-stress response. Inhibits PCSK9-enhanced LDLR degradation, probably reduces PCSK9 protein levels via a translational mechanism but also competes with LDLR for binding with PCSK9. Binds to endosomes damaged by phagocytosis of particulate wear debris and participates in endosomal membrane stabilization, thereby limiting NLRP3 inflammasome activation. Required for endothelial cell surface plasmin generation and may support fibrinolytic surveillance and neoangiogenesis. (Microbial infection) Binds M.pneumoniae CARDS toxin, probably serves as one receptor for this pathogen. When ANXA2 is down-regulated by siRNA, less toxin binds to human cells and less vacuolization (a symptom of M.pneumoniae infection) is seen.
Protein Name Annexin A2
Annexin Ii
Annexin-2
Calpactin I Heavy Chain
Calpactin-1 Heavy Chain
Chromobindin-8
Lipocortin Ii
Placental Anticoagulant Protein Iv
Pap-Iv
Protein I
P36
Database Links Reactome: R-HSA-445355
Reactome: R-HSA-6798695
Reactome: R-HSA-75205
Reactome: R-HSA-8950505
Reactome: R-HSA-9860927
Cellular Localisation Secreted
Extracellular Space
Extracellular Matrix
Basement Membrane
Melanosome
In The Lamina Beneath The Plasma Membrane
Identified By Mass Spectrometry In Melanosome Fractions From Stage I To Stage Iv
Translocated From The Cytoplasm To The Cell Surface Through A Golgi-Independent Mechanism
Alternative Protein Names Annexin A2 protein
Annexin Ii protein
Annexin-2 protein
Calpactin I Heavy Chain protein
Calpactin-1 Heavy Chain protein
Chromobindin-8 protein
Lipocortin Ii protein
Placental Anticoagulant Protein Iv protein
Pap-Iv protein
Protein I protein
P36 protein
ANXA2 protein
ANX2 protein
ANX2L4 protein
CAL1H protein
LPC2D protein

Information sourced from Uniprot.org

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