Human Aminopeptidase N/CD13 protein (Recombinant) (C-His) (STJP002597)

SKU:
STJP002597

£139.50 - £493.50
Current Stock:
Host: HEK293 cells
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Formulation: Lyophilised from a 0.22 Mu m filtered solution of PBS, pH 7.4.
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Determination Method: < 0.1 EU/Mu g of the protein by LAL method.
Immunoreactivity: Measured by its ability to cleave the fluorogenic peptide substrate, Ala-7-amido-4-methylcoumarin (Ala-AMC). The specific activity is >4300 pmol/min/Mu g.
Gene Symbol: ANPEP
Gene ID: 290
Uniprot ID: AMPN_HUMAN
Immunogen Region: Lys69-Lys967
Immunogen: Recombinant Human Aminopeptidase N/CD13 Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (Lys69-Lys967) of human ANPEP/CD13 (Accession #NP_001141.2) fused with an 8×His tag at the C-terminus.
Immunogen Sequence: KAWNRYRLPNTLKPDSYRVT LRPYLTPNDRGLYVFKGSST VRFTCKEATDVIIIHSKKLN YTLSQGHRVVLRGVGGSQPP DIDKTELVEPTEYLVVHLKG SLVKDSQYEMDSEFEGELAD DLAGFYRSEYMEGNVRKVVA TTQMQAADARKSFPCFDEPA MKAEFNITLIHPKDLTALSN MLPKGPSTPLPEDPNWNVTE FHTTPKMSTYLLAFIVSEFD YVEKQASNGVLIRIWARPS
Post Translational Modifications Sulfated. N- and O-glycosylated. May undergo proteolysis and give rise to a soluble form.
Function Broad specificity aminopeptidase which plays a role in the final digestion of peptides generated from hydrolysis of proteins by gastric and pancreatic proteases. Also involved in the processing of various peptides including peptide hormones, such as angiotensin III and IV, neuropeptides, and chemokines. May also be involved the cleavage of peptides bound to major histocompatibility complex class II molecules of antigen presenting cells. May have a role in angiogenesis and promote cholesterol crystallization. May have a role in amino acid transport by acting as binding partner of amino acid transporter SLC6A19 and regulating its activity. (Microbial infection) Acts as a receptor for human coronavirus 229E/HCoV-229E. In case of human coronavirus 229E (HCoV-229E) infection, serves as receptor for HCoV-229E spike glycoprotein. (Microbial infection) Mediates as well Human cytomegalovirus (HCMV) infection.
Protein Name Aminopeptidase N
Ap-N
Hapn
Alanyl Aminopeptidase
Aminopeptidase M
Ap-M
Microsomal Aminopeptidase
Myeloid Plasma Membrane Glycoprotein Cd13
Gp150
Cd Antigen Cd13
Database Links Reactome: R-HSA-2022377
Reactome: R-HSA-6798695
Cellular Localisation Cell Membrane
Single-Pass Type Ii Membrane Protein
Also Found As A Soluble Form
Alternative Protein Names Aminopeptidase N protein
Ap-N protein
Hapn protein
Alanyl Aminopeptidase protein
Aminopeptidase M protein
Ap-M protein
Microsomal Aminopeptidase protein
Myeloid Plasma Membrane Glycoprotein Cd13 protein
Gp150 protein
Cd Antigen Cd13 protein
ANPEP protein
APN protein
CD13 protein
PEPN protein

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance