Function | Is able to inhibit all four classes of proteinases by a unique 'trapping' mechanism. This protein has a peptide stretch, called the 'bait region' which contains specific cleavage sites for different proteinases. When a proteinase cleaves the bait region, a conformational change is induced in the protein which traps the proteinase. The entrapped enzyme remains active against low molecular weight substrates (activity against high molecular weight substrates is greatly reduced). Following cleavage in the bait region, a thioester bond is hydrolyzed and mediates the covalent binding of the protein to the proteinase. |
Protein Name | Alpha-2-MacroglobulinAlpha-2-MC3 And Pzp-Like Alpha-2-Macroglobulin Domain-Containing Protein 5 |
Database Links | Reactome: R-HSA-114608Reactome: R-HSA-140837Reactome: R-HSA-1474228Reactome: R-HSA-8963896 |
Cellular Localisation | Secreted |
Alternative Antibody Pair Names | Alpha-2-Macroglobulin antibody pairAlpha-2-M antibody pairC3 And Pzp-Like Alpha-2-Macroglobulin Domain-Containing Protein 5 antibody pairA2M antibody pairCPAMD5 antibody pairFWP007 antibody pair |
Information sourced from Uniprot.org