Human AKR7A2 protein (Recombinant) (N-His) (STJP010672)

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STJP010672
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Host: E. coli
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Recombinant-Human AKR7A2-N-His protein was developed from e. coli and has a target region of N-His. For use in research applications.
Formulation: Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Storage Instruction: Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt.
Gene Symbol: AKR7A2
Gene ID: 8574
Uniprot ID: ARK72_HUMAN
Immunogen Region: Arg37-Asn356
Immunogen: Homo sapiens (Human)
Function Catalyzes the NADPH-dependent reduction of succinic semialdehyde to gamma-hydroxybutyrate. May have an important role in producing the neuromodulator gamma-hydroxybutyrate (GHB). Has broad substrate specificity. Has NADPH-dependent aldehyde reductase activity towards 2-carboxybenzaldehyde, 2-nitrobenzaldehyde and pyridine-2-aldehyde (in vitro). Can reduce 1,2-naphthoquinone and 9,10-phenanthrenequinone (in vitro). Can reduce the dialdehyde protein-binding form of aflatoxin B1 (AFB1) to the non-binding AFB1 dialcohol. May be involved in protection of liver against the toxic and carcinogenic effects of AFB1, a potent hepatocarcinogen.
Protein Name Aflatoxin B1 Aldehyde Reductase Member 2
Afb1 Aldehyde Reductase 1
Afb1-Ar 1
Aldoketoreductase 7
Succinic Semialdehyde Reductase
Ssa Reductase
Database Links Reactome: R-HSA-5423646
Cellular Localisation Mitochondrion
Golgi Apparatus
Cytoplasm
Alternative Protein Names Aflatoxin B1 Aldehyde Reductase Member 2 protein
Afb1 Aldehyde Reductase 1 protein
Afb1-Ar 1 protein
Aldoketoreductase 7 protein
Succinic Semialdehyde Reductase protein
Ssa Reductase protein
AKR7A2 protein
AFAR protein
AFAR1 protein
AKR7 protein

Information sourced from Uniprot.org

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