Human AKR1C3 protein (Recombinant) (N-His) (STJP008204)

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STJP008204
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Host: E. coli
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Recombinant-Human AKR1C3-N-His protein was developed from e. coli and has a target region of N-His. For use in research applications.
Formulation: Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Storage Instruction: Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt.
Gene Symbol: AKR1C3
Gene ID: 8644
Uniprot ID: AK1C3_HUMAN
Immunogen Region: Met1-Tyr323
Immunogen: Homo sapiens (Human)
Function Cytosolic aldo-keto reductase that catalyzes the NADH and NADPH-dependent reduction of ketosteroids to hydroxysteroids. Acts as a NAD(P)(H)-dependent 3-, 17- and 20-ketosteroid reductase on the steroid nucleus and side chain and regulates the metabolism of androgens, estrogens and progesterone. Displays the ability to catalyze both oxidation and reduction in vitro, but most probably acts as a reductase in vivo since the oxidase activity measured in vitro is inhibited by physiological concentration of NADPH. Acts preferentially as a 17-ketosteroid reductase and has the highest catalytic efficiency of the AKR1C enzyme for the reduction of delta4-androstenedione to form testosterone. Reduces prostaglandin (PG) D2 to 11beta-prostaglandin F2, progesterone to 20alpha-hydroxyprogesterone and estrone to 17beta-estradiol. Catalyzes the transformation of the potent androgen dihydrotestosterone (DHT) into the less active form, 5-alpha-androstan-3-alpha,17-beta-diol (3-alpha-diol). Also displays retinaldehyde reductase activity toward 9-cis-retinal.
Protein Name Aldo-Keto Reductase Family 1 Member C3
17-Beta-Hydroxysteroid Dehydrogenase Type 5
17-Beta-Hsd 5
3-Alpha-Hsd Type Ii - Brain
3-Alpha-Hydroxysteroid Dehydrogenase Type 2
3-Alpha-Hsd Type 2
Chlordecone Reductase Homolog Hakrb
Dihydrodiol Dehydrogenase 3
Dd-3
Dd3
Dihydrodiol Dehydrogenase Type I
Ha1753
Prostaglandin F Synthase
Pgfs
Testosterone 17-Beta-Dehydrogenase 5
Database Links Reactome: R-HSA-193368
Reactome: R-HSA-193775
Reactome: R-HSA-193807
Reactome: R-HSA-2162123
Reactome: R-HSA-5365859
Reactome: R-HSA-975634
Cellular Localisation Cytoplasm
Alternative Protein Names Aldo-Keto Reductase Family 1 Member C3 protein
17-Beta-Hydroxysteroid Dehydrogenase Type 5 protein
17-Beta-Hsd 5 protein
3-Alpha-Hsd Type Ii - Brain protein
3-Alpha-Hydroxysteroid Dehydrogenase Type 2 protein
3-Alpha-Hsd Type 2 protein
Chlordecone Reductase Homolog Hakrb protein
Dihydrodiol Dehydrogenase 3 protein
Dd-3 protein
Dd3 protein
Dihydrodiol Dehydrogenase Type I protein
Ha1753 protein
Prostaglandin F Synthase protein
Pgfs protein
Testosterone 17-Beta-Dehydrogenase 5 protein
AKR1C3 protein
DDH1 protein
HSD17B5 protein
KIAA0119 protein
PGFS protein

Information sourced from Uniprot.org

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