Human AICDA protein (Recombinant) (His-Tag) (STJP018002)

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STJP018002
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Host: E.coli
Applications: SDS-PAGE/Denatured
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Recombinant-Human AICDA-His-Tag protein was developed from e.coli and has a target region of His-Tag. For use in research applications.
Formulation: Liquid in 20mM Tris-HCl buffer (pH 8.0) containing 0.4M urea, 10% Glycerol
Concentration: 0.5 mg/mL
Storage Instruction: For short term storage, keep at +2C to +8C for up to 1 week. For long term storage, aliquot and store at-20C, and avoid repeat freeze-thaw cycles.
Gene Symbol: AICDA
Gene ID: 57379
Uniprot ID: AICDA_HUMAN
Immunogen Region: 1-198aa
Accession Number: NP_065712.1
Immunogen: Human
Immunogen Sequence: MDSLLMNRRK FLYQFKNVRW AKGRRETYLC YVVKRRDSAT SFSLDFGYLR NKNGCHVELL FLRYISDWDL DPGRCYRVTW FTSWSPCYDC ARHVADFLRG NPNLSLRIFT ARLYFCEDRK AEPEGLRRLH RAGVQIAIMT FKDYFYCWNT FVENHERTFK AWEGLHENSV RLSRQLRRIL LPLYEVDDLR DAFRTLGL
Tissue Specificity Strongly expressed in lymph nodes and tonsils.
Post Translational Modifications Ser-38 is the major site whereas Thr-27 is the minor site of phosphorylation. Phosphorylation regulates its class-switch recombination activity. Probably monoubiquitinated on several residues by RNF126.
Function Single-stranded DNA-specific cytidine deaminase. Involved in somatic hypermutation (SHM), gene conversion, and class-switch recombination (CSR) in B-lymphocytes by deaminating C to U during transcription of Ig-variable (V) and Ig-switch (S) region DNA. Required for several crucial steps of B-cell terminal differentiation necessary for efficient antibody responses. May also play a role in the epigenetic regulation of gene expression by participating in DNA demethylation.
Protein Name Single-Stranded Dna Cytosine Deaminase
Activation-Induced Cytidine Deaminase
Aid
Cytidine Aminohydrolase
Database Links Reactome: R-HSA-9821002
Cellular Localisation Nucleus
Cytoplasm
Cytosol
Predominantly Cytosolic
In The Presence Of Mcm3ap/Ganp
Relocalizes To The Nucleus
Alternative Protein Names Single-Stranded Dna Cytosine Deaminase protein
Activation-Induced Cytidine Deaminase protein
Aid protein
Cytidine Aminohydrolase protein
AICDA protein
AID protein

Information sourced from Uniprot.org

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