Human ADI1 protein (Recombinant) (His-Tag) (STJP018082)

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STJP018082
€161.40 - €886.20
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Short Description :Recombinant-Human ADI1-His-Tag protein was developed from e.coli and has a target region of His-Tag. For use in research applications.
Applications:SDS-PAGE
Host:E.coli
Note:STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Concentration:0.5 mg/mL
Formulation:Liquid in 20mM Tris-HCl buffer (pH 8.0) containing 0.15M NaCl, 10% Glycerol, 1mM DTT
Storage Instruction:For short term storage, keep at +2C to +8C for up to 1 week. For long term storage, aliquot and store at-20C, and avoid repeat freeze-thaw cycles.
Gene Symbol:ADI1
Gene ID:55256
Uniprot ID:MTND_HUMAN
Accession Number:NP_060739
Immunogen:Human
Immunogen Region:1-179aa
Immunogen Sequence:MRGSHHHHHH GMASMTGGQQ MGRDLYDDDD KDRWGSSMVL AWYMDDAPGD PRQPHRPDPG RPVGLEQLRR LGVLYWKLDA DKYENDPELE KIRRERNYSW MDIITICKDK LPNYEEKIKM FYEEHLHLDD EIRYILDGSG YFDVRDKEDQ WIRIFMEKGD MVTLPAGIYH RFTVDEKNYT KAMRLFVGEP VWTAYNRPAD HFEARGQYVK FLAQTA
Tissue Specificity Detected in heart, colon, lung, stomach, brain, spleen, liver, skeletal muscle and kidney.
Function Catalyzes 2 different reactions between oxygen and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4-methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway. Also down-regulates cell migration mediated by MMP14. Necessary for hepatitis C virus replication in an otherwise non-permissive cell line.
Protein Name Acireductone Dioxygenase
Acireductone Dioxygenase
Fe(2+-Requiring
Ard'
Fe-Ard
Acireductone Dioxygenase
Ni(2+-Requiring
Ard
Ni-Ard
Membrane-Type 1 Matrix Metalloproteinase Cytoplasmic Tail-Binding Protein 1
Mtcbp-1
Submergence-Induced Protein-Like Factor
Sip-L
Database Links Reactome: R-HSA-1237112
Cellular Localisation Cytoplasm
Nucleus
Cell Membrane
Peripheral Membrane Protein
Cytoplasmic Side
Localizes To The Plasma Membrane When Complexed To Mmp14
Alternative Protein Names Acireductone Dioxygenase protein
Acireductone Dioxygenase protein
Fe(2+-Requiring protein
Ard' protein
Fe-Ard protein
Acireductone Dioxygenase protein
Ni(2+-Requiring protein
Ard protein
Ni-Ard protein
Membrane-Type 1 Matrix Metalloproteinase Cytoplasmic Tail-Binding Protein 1 protein
Mtcbp-1 protein
Submergence-Induced Protein-Like Factor protein
Sip-L protein
ADI1 protein
MTCBP1 protein
HMFT1638 protein

Information sourced from Uniprot.org

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