| Tissue Specificity | Detected in skeletal muscle, and in jejunum brush border membrane and basolateral membrane (at protein level). Expressed in small intestine, and at much lower levels in kidney, skeletal muscle, and adipose tissue. |
| Function | Functions as a fructose transporter that has only low activity with other monosaccharides. Can mediate the uptake of 2-deoxyglucose, but with low efficiency. Essential for fructose uptake in the small intestine. Plays a role in the regulation of salt uptake and blood pressure in response to dietary fructose. Required for the development of high blood pressure in response to high dietary fructose intake. |
| Peptide Name | Solute Carrier Family 2 - Facilitated Glucose Transporter Member 5Fructose TransporterGlucose Transporter Type 5 - Small IntestineGlut-5 |
| Database Links | Reactome: R-HSA-6798695Reactome: R-HSA-8981373 |
| Cellular Localisation | Apical Cell MembraneMulti-Pass Membrane ProteinCell MembraneSarcolemmaLocalized On The Apical Membrane Of Jejunum VilliBut Also On Lateral Plasma Membranes Of The VilliTransport To The Cell Membrane Is Dependent On Rab11a |
| Alternative Peptide Names | Solute Carrier Family 2 - Facilitated Glucose Transporter Member 5 proteinFructose Transporter proteinGlucose Transporter Type 5 - Small Intestine proteinGlut-5 proteinSLC2A5 proteinGLUT5 protein |
Information sourced from Uniprot.org
