Glucose Transporter GLUT4 Blocking Peptide is synthetically produced from the 450-509 sequence and is suitable for use in western blot applications.
Applications
Immunodepletion/Immunocompetition
Note
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Product Properties
Formulation
Liquid form at 2.5mg/ml concentration in PBS. Up to 5% DMSO can be added. Orders with >1mg can be supplied in lyophilized powder form, or in buffer of choice.
Storage Instruction
Store at-20°C for long term storage. Avoid freeze-thaw cycles.
Synthetic peptide taken within amino acid region 450-509 on mouse Solute carrier family 2, facilitated glucose transporter member 4 protein.
Immunogen Region
450-509
Additional Info
Tissue Specificity
Expressed in skeletal and cardiac muscles. Expressed in brown and white adipose tissues.
Post Translational Modifications
Sumoylated. Palmitoylated. Palmitoylation by ZDHHC7 controls the insulin-dependent translocation of GLUT4 to the plasma membrane.
Function
Insulin-regulated facilitative glucose transporter, which plays a key role in removal of glucose from circulation. Response to insulin is regulated by its intracellular localization: in the absence of insulin, it is efficiently retained intracellularly within storage compartments in muscle and fat cells. Upon insulin stimulation, translocates from these compartments to the cell surface where it transports glucose from the extracellular milieu into the cell.
Peptide Name
Solute Carrier Family 2 - Facilitated Glucose Transporter Member 4Gt2Glucose Transporter Type 4 - Insulin-ResponsiveGlut-4
Cell MembraneMulti-Pass Membrane ProteinEndomembrane SystemCytoplasmPerinuclear RegionLocalizes Primarily To The Perinuclear RegionUndergoing Continued Recycling To The Plasma Membrane Where It Is Rapidly ReinternalizedThe Dileucine Internalization Motif Is Critical For Intracellular SequestrationInsulin Stimulation Induces Translocation To The Cell Membrane
Alternative Peptide Names
Solute Carrier Family 2 - Facilitated Glucose Transporter Member 4 proteinGt2 proteinGlucose Transporter Type 4 - Insulin-Responsive proteinGlut-4 proteinSlc2a4 proteinGlut4 protein
