| Applications: |
Immunodepletion/Immunocompetition |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
FOLR1 Blocking Peptide for STJ501071 is synthetically produced from the 200-250 sequence and is suitable for use in western blot applications. |
| Formulation: |
Liquid form at 2.5mg/ml concentration in PBS. Up to 5% DMSO can be added. Orders with >1mg can be supplied in lyophilized powder form, or in buffer of choice. |
| Storage Instruction: |
Store at-20°C for long term storage. Avoid freeze-thaw cycles. |
| Gene Symbol: |
Folr1 |
| Gene ID: |
14275 |
| Uniprot ID: |
FOLR1_MOUSE |
| Immunogen Region: |
200-250 |
| Specificity: |
This blocking peptide is recommended for use in combination with FOLR1 antibody, STJ501071 |
| Immunogen: |
Synthetic peptide taken within amino acid region 200-250 on mouse Folate receptor alpha protein. |
| Tissue Specificity | Detected in kidney proximal tubules (at protein level). |
| Post Translational Modifications | The secreted form is derived from the membrane-bound form either by cleavage of the GPI anchor, or/and by proteolysis catalyzed by a metalloprotease. |
| Function | Binds to folate and reduced folic acid derivatives and mediates delivery of 5-methyltetrahydrofolate and folate analogs into the interior of cells. Has high affinity for folate and folic acid analogs at neutral pH. Exposure to slightly acidic pH after receptor endocytosis triggers a conformation change that strongly reduces its affinity for folates and mediates their release. Required for normal embryonic development and normal cell proliferation. Required for renal folate reabsorption. |
| Peptide Name | Folate Receptor AlphaFr-AlphaFolate Receptor 1Folate-Binding Protein 1 |
| Database Links | Reactome: R-MMU-204005Reactome: -MMU-5694530Reactome: -MMU-6807878 |
| Cellular Localisation | Cell MembraneLipid-AnchorGpi-AnchorApical Cell MembraneBasolateral Cell MembraneGpi-Like-AnchorSecretedCytoplasmic VesicleClathrin-Coated VesicleEndosomeEndocytosed Into Cytoplasmic Vesicles And Then Recycled To The Cell Membrane |
| Alternative Peptide Names | Folate Receptor Alpha proteinFr-Alpha proteinFolate Receptor 1 proteinFolate-Binding Protein 1 proteinFolr1 proteinFbp1 proteinFolbp1 protein |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
