| Applications: | Immunodepletion/Immunocompetition |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | ELOVL1 Blocking Peptide for STJ500870 is synthetically produced from the 148-198 sequence and is suitable for use in western blot applications. |
| Formulation: | Liquid form at 2.5mg/ml concentration in PBS. Up to 5% DMSO can be added. Orders with >1mg can be supplied in lyophilized powder form, or in buffer of choice. |
| Storage Instruction: | Store at-20°C for long term storage. Avoid freeze-thaw cycles. |
| Gene Symbol: | ELOVL1 |
| Gene ID: | 64834 |
| Uniprot ID: | ELOV1_HUMAN |
| Immunogen Region: | 148-198 |
| Specificity: | This blocking peptide is recommended for use in combination with ELOVL1 antibody, STJ500870 |
| Immunogen: | Synthetic peptide taken within amino acid region 148-198 on human Elongation of very long chain fatty acids protein 1. |
| Tissue Specificity | Ubiquitous. |
| Function | Catalyzes the first and rate-limiting reaction of the four reactions that constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids (VLCFAs) per cycle. Condensing enzyme that exhibits activity toward saturated and monounsaturated acyl-CoA substrates, with the highest activity towards C22:0 acyl-CoA. May participate in the production of both saturated and monounsaturated VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators. Important for saturated C24:0 and monounsaturated C24:1 sphingolipid synthesis. Indirectly inhibits RPE65 via production of VLCFAs. |
| Peptide Name | Very Long Chain Fatty Acid Elongase 1 3-Keto Acyl-Coa Synthase Elovl1 Elovl Fatty Acid Elongase 1 Elovl Fa Elongase 1 Elongation Of Very Long Chain Fatty Acids Protein 1 Very Long Chain 3-Ketoacyl-Coa Synthase 1 Very Long Chain 3-Oxoacyl-Coa Synthase 1 |
| Database Links | Reactome: R-HSA-2046105 Reactome: R-HSA-2046106 Reactome: R-HSA-75876 |
| Cellular Localisation | Endoplasmic Reticulum Membrane Multi-Pass Membrane Protein |
| Alternative Peptide Names | Very Long Chain Fatty Acid Elongase 1 protein 3-Keto Acyl-Coa Synthase Elovl1 protein Elovl Fatty Acid Elongase 1 protein Elovl Fa Elongase 1 protein Elongation Of Very Long Chain Fatty Acids Protein 1 protein Very Long Chain 3-Ketoacyl-Coa Synthase 1 protein Very Long Chain 3-Oxoacyl-Coa Synthase 1 protein ELOVL1 protein SSC1 protein CGI-88 protein |
Information sourced from Uniprot.org