EAAT2 Blocking Peptide peptide (STJ504939)

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STJ504939-250
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Applications: Immunodepletion/Immunocompetition
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : EAAT2 Blocking Peptide is synthetically produced from the 550-574 sequence and is suitable for use in western blot applications.
Formulation: Liquid form at 2.5mg/ml concentration in PBS. Up to 5% DMSO can be added. Orders with >1mg can be supplied in lyophilized powder form, or in buffer of choice.
Storage Instruction: Store at-20°C for long term storage. Avoid freeze-thaw cycles.
Gene Symbol: SLC1A2
Gene ID: 6506
Uniprot ID: EAA2_HUMAN
Immunogen Region: 550-574
Immunogen: Synthetic peptide corresponding to C terminal amino acids 550-574 of Human EAAT2. Sequence: KVTLAANGKSADCSVEEEPWKREK
Post Translational Modifications Glycosylated. Palmitoylation at Cys-38 is not required for correct subcellular localization, but is important for glutamate uptake activity.
Function Sodium-dependent, high-affinity amino acid transporter that mediates the uptake of L-glutamate and also L-aspartate and D-aspartate. Functions as a symporter that transports one amino acid molecule together with two or three Na(+) ions and one proton, in parallel with the counter-transport of one K(+) ion. Mediates Cl(-) flux that is not coupled to amino acid transport.this avoids the accumulation of negative charges due to aspartate and Na(+) symport. Essential for the rapid removal of released glutamate from the synaptic cleft, and for terminating the postsynaptic action of glutamate.
Peptide Name Excitatory Amino Acid Transporter 2
Glutamate/Aspartate Transporter Ii
Sodium-Dependent Glutamate/Aspartate Transporter 2
Solute Carrier Family 1 Member 2
Database Links Reactome: R-HSA-210455
Reactome: R-HSA-210500
Reactome: R-HSA-425393
Cellular Localisation Cell Membrane
Multi-Pass Membrane Protein
Alternative Peptide Names Excitatory Amino Acid Transporter 2 protein
Glutamate/Aspartate Transporter Ii protein
Sodium-Dependent Glutamate/Aspartate Transporter 2 protein
Solute Carrier Family 1 Member 2 protein
SLC1A2 protein
EAAT2 protein
GLT1 protein

Information sourced from Uniprot.org

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