| Applications: |
Immunodepletion/Immunocompetition |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
DAPK2 Blocking Peptide for STJ500731 is synthetically produced from the 300-350 sequence and is suitable for use in western blot applications. |
| Formulation: |
Liquid form at 2.5mg/ml concentration in PBS. Up to 5% DMSO can be added. Orders with >1mg can be supplied in lyophilized powder form, or in buffer of choice. |
| Storage Instruction: |
Store at-20°C for long term storage. Avoid freeze-thaw cycles. |
| Gene Symbol: |
Dapk2 |
| Gene ID: |
13143 |
| Uniprot ID: |
DAPK2_MOUSE |
| Immunogen Region: |
300-350 |
| Specificity: |
This blocking peptide is recommended for use in combination with DAPK2 antibody, STJ500731 |
| Immunogen: |
Synthetic peptide take within amino acid region 300-350 on mouse Death-associated protein kinase 2 protein. |
| Tissue Specificity | Expressed in peritubular interstitial cells of the renal cortex. Isoform 1 is found in the adult brain while isoform 2 is expressed in brains of embryos and young mice (at protein level). |
| Post Translational Modifications | Autophosphorylation at Ser-318 inhibits its catalytic activity. Dephosphorylated at Ser-318 in response to activated Fas and TNF-alpha receptors. |
| Function | Calcium/calmodulin-dependent serine/threonine kinase involved in multiple cellular signaling pathways that trigger cell survival, apoptosis, and autophagy. Capable of regulating both type I apoptotic and type II autophagic cell death signals. The former involves caspase activation, chromatin and mitochondrial condensation while the latter involves caspase-independent cell death in conjunction with accumulation of mature autophagic vesicles, plasma membrane blebs, and nuclear condensation without DNA degradation. Mediator of anoikis and a suppressor of beta-catenin-dependent anchorage-independent growth of malignant epithelial cells. May play a role in granulocytic maturation. Regulates granulocytes motility by controlling cell spreading and polarization. |
| Peptide Name | Death-Associated Protein Kinase 2Dap Kinase 2Dap-Kinase-Related Protein 1Drp-1 |
| Cellular Localisation | CytoplasmCytoplasmic VesicleAutophagosome Lumen |
| Alternative Peptide Names | Death-Associated Protein Kinase 2 proteinDap Kinase 2 proteinDap-Kinase-Related Protein 1 proteinDrp-1 proteinDapk2 protein |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
