| Applications: |
Immunodepletion/Immunocompetition |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
D4S234E Blocking Peptide for STJ501974 is synthetically produced from the 140-190 sequence and is suitable for use in western blot applications. |
| Formulation: |
Liquid form at 2.5mg/ml concentration in PBS. Up to 5% DMSO can be added. Orders with >1mg can be supplied in lyophilized powder form, or in buffer of choice. |
| Storage Instruction: |
Store at-20°C for long term storage. Avoid freeze-thaw cycles. |
| Gene Symbol: |
Nsg1 |
| Gene ID: |
25247 |
| Uniprot ID: |
NSG1_RAT |
| Immunogen Region: |
140-190 |
| Specificity: |
This blocking peptide is recommended for use in combination with D4S234E antibody, STJ501974 |
| Immunogen: |
Synthetic peptide taken within amino acid region 140-190 on human Neuron-specific protein family member 1. |
| Tissue Specificity | Widely expressed in brain and spinal cord. Expressed in neurons during maturation and synapse formation. |
| Function | Plays a role in the recycling mechanism in neurons of multiple receptors, including AMPAR, APP and L1CAM and acts at the level of early endosomes to promote sorting of receptors toward a recycling pathway. Regulates sorting and recycling of GRIA2 through interaction with GRIP1 and then contributes to the regulation of synaptic transmission and plasticity by affecting the recycling and targeting of AMPA receptors to the synapse. Is required for faithful sorting of L1CAM to axons by facilitating trafficking from somatodendritic early endosome or the recycling endosome. In an other hand, induces apoptosis via the activation of CASP3 in response to DNA damage. |
| Peptide Name | Neuronal Vesicle Trafficking-Associated Protein 1Brain Neuron Cytoplasmic Protein 1/2Neuron-Enriched Endosomal Protein Of 21 KdaNeuron-Specific Protein Family Member 1 |
| Cellular Localisation | MembraneSingle-Pass Type Ii Membrane ProteinGolgi ApparatusTrans-Golgi Network MembraneEndosome MembraneCell ProjectionDendriteEarly Endosome MembraneLate Endosome MembraneLysosome LumenRecycling Endosome MembraneCytoplasmic Vesicle MembraneGolgi Stack MembraneEndosomeMultivesicular Body MembraneEndoplasmic Reticulum MembraneEndocytosed From The Cell SurfaceThus Enters Into Early EndosomesTrafficks To Late Endosomes And Degradates In LysosomesEndoplasmic Reticulum Targeting Is Essential For ApoptosisFound In Both Stationary And Motile EndosomesA Previous Study Supports A Type I Membrane Protein Topology |
| Alternative Peptide Names | Neuronal Vesicle Trafficking-Associated Protein 1 proteinBrain Neuron Cytoplasmic Protein 1/2 proteinNeuron-Enriched Endosomal Protein Of 21 Kda proteinNeuron-Specific Protein Family Member 1 proteinNsg1 proteinBsmrb protein |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
