| Short Description : | Recombinant-Cynomolgus CD3E&CD3D-C-hFc protein was developed in hek293 cells using the region Asp20-Arg687. For use in research applications. |
| Host: | HEK293 cells |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Conjugation: | Unconjugated |
| Formulation: | Lyophilised from a 0.2 Mu m filtered solution of PBS, pH 7.4.Contact us for customized product form or formulation. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Determination Method: | < 0.1 EU/Mu g of the protein by LAL method. |
| Immunogen: | Recombinant Cynomolgus CD3E&CD3G Protein is produced by mammalian expression system. The target protein is expressed with sequence (Asp20-Arg687 (Q95LI52) & Phe22-Ala105 (Q95LI8) ) of cynomolgus CD3E&CD3D (Accession #Q95LI5.2 & Q95LI8) fused with an |
| Immunogen Region: | Asp20-Arg687 |
| Immunogen Sequence: | QDGNEEMGSITQTPYQVSIS GTTVILTCSQHLGSEAQWQH NGKNKEDSGDRLFLPEFSEM EQSGYYVCYPRGSNPEDASH HLYLKARVCENCMEMDFKIP VEELEDRVFVKCNTSVTWVE GTVGTLLTNNTRLDLGKRIL DPRGIYRCNGTDIYKDKESA VQVHYRMCQNCVELDPATLA |
| Background | T-cell surface glycoprotein CD3 epsilon & CD3 delta chain, also known as CD3E & CD3D, are single-pass type I membrane proteins.When antigen presenting cells (APCs) activate T-cell receptor (TCR) , TCR-mediated signals are transmitted across the cell membrane by the CD3 chains CD3D, CD3E, CD3G and CD3Z. All CD3 chains contain immunoreceptor tyrosine-based activation motifs (ITAMs) in their cytoplasmic domain. |
Information sourced from Uniprot.org
