| Host: | HEK293 cells |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Conjugation: | Unconjugated |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Determination Method: | < 1 EU/Mu g of the protein by LAL method. |
| Immunogen Region: | Ile21-Met119 |
| Immunogen: | Recombinant Cynomolgus Beta-2-Microglobulin/B2M Protein is produced by Expi293 expression system. The target protein is expressed with sequence ( Ile21-Met119) of Cynomolgus Beta-2-Microglobulin fused with His tag at the C-terminus. |
| Background | The genetic and functional analysis of Beta 2-microglobulin (B2M) , a component of the HLA class-I complex.Acquired homozygous loss of B2M that caused lack of cell-surface HLA Class I expression in the tumor and a matched patient-derived xenograft (PDX). Downregulation of B2M was also found in two additional PDXs established from ICI-resistant tumors. |
Information sourced from Uniprot.org
