Tissue Specificity | Highest levels in the brain and pancreas. Also expressed in the heart, placenta, and weakly in the kidney and liver. Expression is much reduced in the malignant gliomas, compared to normal brain or low-grade astrocytomas. |
Function | GTPase-activating protein for p21-rac. Insufficient expression of beta-2 chimaerin is expected to lead to higher Rac activity and could therefore play a role in the progression from low-grade to high-grade tumors. |
Peptide Name | Beta-ChimaerinBeta-ChimerinRho Gtpase-Activating Protein 3 |
Database Links | Reactome: R-HSA-9013149 |
Cellular Localisation | MembranePeripheral Membrane Protein |
Alternative Peptide Names | Beta-Chimaerin proteinBeta-Chimerin proteinRho Gtpase-Activating Protein 3 proteinCHN2 proteinARHGAP3 proteinBCH protein |
Information sourced from Uniprot.org