| Applications: |
Immunodepletion/Immunocompetition |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Chimaerin beta 2 Blocking Peptide is synthetically produced from the 150-180 sequence and is suitable for use in western blot applications. |
| Formulation: |
Liquid form at 2.5mg/ml concentration in PBS. Up to 5% DMSO can be added. Orders with >1mg can be supplied in lyophilized powder form, or in buffer of choice. |
| Storage Instruction: |
Store at-20°C for long term storage. Avoid freeze-thaw cycles. |
| Gene Symbol: |
CHN2 |
| Gene ID: |
1124 |
| Uniprot ID: |
CHIO_HUMAN |
| Immunogen Region: |
150-180 |
| Immunogen: |
Synthetic peptide taken within amino acid region 150-180 on beta 2-chimaerin protein. |
| Tissue Specificity | Highest levels in the brain and pancreas. Also expressed in the heart, placenta, and weakly in the kidney and liver. Expression is much reduced in the malignant gliomas, compared to normal brain or low-grade astrocytomas. |
| Function | GTPase-activating protein for p21-rac. Insufficient expression of beta-2 chimaerin is expected to lead to higher Rac activity and could therefore play a role in the progression from low-grade to high-grade tumors. |
| Peptide Name | Beta-ChimaerinBeta-ChimerinRho Gtpase-Activating Protein 3 |
| Database Links | Reactome: R-HSA-9013149 |
| Cellular Localisation | MembranePeripheral Membrane Protein |
| Alternative Peptide Names | Beta-Chimaerin proteinBeta-Chimerin proteinRho Gtpase-Activating Protein 3 proteinCHN2 proteinARHGAP3 proteinBCH protein |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
