CD39 Blocking Peptide peptide (STJ505689)
SPECIFICATIONS
ImmunogenSynthetic peptide taken within amino acid region 440-490 on human EctoNucleoside TriPhosphate Diphosphohydrolase 1.
General Information
| Short Description | CD39 Blocking Peptide is synthetically produced from the 440-490 sequence and is suitable for use in western blot applications. |
| Applications | Immunodepletion/Immunocompetition |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Formulation | Liquid form at 2.5mg/ml concentration in PBS. Up to 5% DMSO can be added. Orders with >1mg can be supplied in lyophilized powder form, or in buffer of choice. |
| Storage Instruction | Store at-20ยฐC for long term storage. Avoid freeze-thaw cycles. |
Target Information
| Gene Symbol | ENTPD1 |
| Gene ID | 953 |
| Uniprot ID | ENTP1_HUMAN |
| Immunogen | Synthetic peptide taken within amino acid region 440-490 on human EctoNucleoside TriPhosphate Diphosphohydrolase 1. |
| Immunogen Region | 440-490 |
Additional Info
| Tissue Specificity | Expressed primarily on activated lymphoid cells. Also expressed in endothelial tissues. Highly expressed in placenta, lung, skeletal muscle, kidney. |
| Post Translational Modifications | N-glycosylated. The N-terminus is blocked. Palmitoylated on Cys-13.which is required for caveola targeting. |
| Function | Catalyzes the hydrolysis of both di- and triphosphate nucleotides (NDPs and NTPs) and hydrolyze NTPs to nucleotide monophosphates (NMPs) in two distinct successive phosphate-releasing steps, with NDPs as intermediates and participates in the regulation of extracellular levels of nucleotides (Probable). By hydrolyzing proinflammatory ATP and platelet-activating ADP to AMP, it blocks platelet aggregation and supports blood flow. |
| Peptide Name | Ectonucleoside Triphosphate Diphosphohydrolase 1Atp DiphosphohydrolaseAtp-DphAtpdaseEcto-Atp Diphosphohydrolase 1Ecto-Atpdase 1Ecto-Atpase 1Ecto-ApyraseLymphoid Cell Activation AntigenNucleoside Triphosphate Diphosphohydrolase 1Ntpdase1Cd Antigen Cd39 |
| Database Links | Reactome: R-HSA-8850843Reactome: R-HSA-9660826 |
| Cellular Localisation | MembraneMulti-Pass Membrane ProteinCaveola |
| Alternative Peptide Names | Ectonucleoside Triphosphate Diphosphohydrolase 1 proteinAtp Diphosphohydrolase proteinAtp-Dph proteinAtpdase proteinEcto-Atp Diphosphohydrolase 1 proteinEcto-Atpdase 1 proteinEcto-Atpase 1 proteinEcto-Apyrase proteinLymphoid Cell Activation Antigen proteinNucleoside Triphosphate Diphosphohydrolase 1 proteinNtpdase1 proteinCd Antigen Cd39 proteinENTPD1 proteinCD39 protein |
Information sourced from Uniprot.org