CCDC98 Blocking Peptide for STJ500022 peptide (STJ503617)
SPECIFICATIONS
ImmunogenSynthetic peptide taken within amino acid region 350-400 on human BRCA1-A complex subunit Abraxas protein.
General Information
| Short Description | CCDC98 Blocking Peptide for STJ500022 is synthetically produced from the 350-400 sequence and is suitable for use in western blot applications. |
| Applications | Immunodepletion/Immunocompetition |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Formulation | Liquid form at 2.5mg/ml concentration in PBS. Up to 5% DMSO can be added. Orders with >1mg can be supplied in lyophilized powder form, or in buffer of choice. |
| Storage Instruction | Store at-20ยฐC for long term storage. Avoid freeze-thaw cycles. |
Target Information
| Gene Symbol | ABRAXAS1 |
| Gene ID | 84142 |
| Uniprot ID | ABRX1_HUMAN |
| Immunogen | Synthetic peptide taken within amino acid region 350-400 on human BRCA1-A complex subunit Abraxas protein. |
| Immunogen Region | 350-400 |
| Specificity | This blocking peptide is recommended for use in combination with CCDC98 antibody, STJ500022 |
Additional Info
| Post Translational Modifications | Phosphorylation of Ser-406 of the pSXXF motif by ATM or ATR constitutes a specific recognition motif for the BRCT domain of BRCA1. Ionizing radiation promotes rapid phosphorylation at Ser-404 and Ser-406 by ATM.this promotes recruitment of BRCA1 to sites of DNA damage. |
| Function | Involved in DNA damage response and double-strand break (DSB) repair. Component of the BRCA1-A complex, acting as a central scaffold protein that assembles the various components of the complex and mediates the recruitment of BRCA1. The BRCA1-A complex specifically recognizes 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesion sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at DSBs. This complex also possesses deubiquitinase activity that specifically removes 'Lys-63'-linked ubiquitin on histones H2A and H2AX. |
| Peptide Name | Brca1-A Complex Subunit Abraxas 1Coiled-Coil Domain-Containing Protein 98Protein Fam175a |
| Database Links | Reactome: R-HSA-5689901Reactome: R-HSA-5693565Reactome: R-HSA-5693571Reactome: R-HSA-5693607Reactome: R-HSA-69473 |
| Cellular Localisation | NucleusLocalizes At Sites Of Dna Damage At Double-Strand Breaks (Dsbs) |
| Alternative Peptide Names | Brca1-A Complex Subunit Abraxas 1 proteinCoiled-Coil Domain-Containing Protein 98 proteinProtein Fam175a proteinABRAXAS1 proteinABRA1 proteinCCDC98 proteinFAM175A proteinUNQ496 proteinPRO1013 protein |
Information sourced from Uniprot.org