Posted by M.Popov on 12th Nov 2020
Trial size CDKN1A antibodies available in the Antibody Validation Project
Trial size CDKN1A antibodies available in the Antibody Validation Project
Introduction:
Cyclin dependent kinase inhibitor 1A is a protein synthesised by the CDKN1A gene and is tightly controlled by the p53. Usually, this gene can be found in immune cells and despite its significance to our body disruptions in the normal expressions or mutations can cause many serious conditions including LFS, different types of cancers, leukemia and a variety of papilloma. It can be used as a prognostic marker for favourable endometrial and renal cancer and unfavourable lung cancer. We provide a number of trial sized antibodies, which are suitable for CDKN1A research purposes, and to help you make the right decision and find the best suited antibody for you, please find the answers to some of the key topics regarding CDKN1A that we have provided in the links below.
- What is CDKN1A ?
- Where is CDKN1A found?
- What role does CDKN1A play in disease?
- CDKN1A antibodies in the Antibody Validation project
- Customer reviewed CDKN1A antibodies
- Other CDKN1A antibodies available in the Antibody Validation Project
- Popular CDKN1A antibodies not currently in the Antibody Validation Project
- How does the Antibody Validation Project work?
What is CDKN1A?
This gene encodes a potent cyclin-dependent kinase inhibitor. The encoded protein binds to and inhibits the activity of cyclin-cyclin-dependent kinase2 or -cyclin-dependent kinase4 complexes, and thus functions as a regulator of cell cycle progression at G1. The expression of this gene is tightly controlled by the tumor suppressor protein p53, through which this protein mediates the p53-dependent cell cycle G1 phase arrest in response to a variety of stress stimuli. Also, this protein can interact with proliferating cell nuclear antigen, a DNA polymerase accessory factor, and plays a regulatory role in S phase DNA replication and DNA damage repair. Cyclin dependent kinase inhibitor 1A was reported to be specifically cleaved by CASP3-like caspases, which thus leads to a dramatic activation of cyclin-dependent kinase2, and may be instrumental in the execution of apoptosis following caspase activation.
Where is CDKN1A found?
CDKN1A is usually found in the nucleoplasm and nuclear bodies and despite having low tissue and brain region specificity it is immune cell enhanced.
What role does CDKN1A play in disease?
Being a cancer-related gene, CDKN1A is responsible for tongue and other forms of cancers. Apart from that, its relation to P53 leads to papilloma if abnormalities occur and bladder transitional cell papilloma if mutations of TP53 occur. Furthermore, if a mutation of the TP53 happens, Li-Fraumeni syndrome can occur.
CDKN1A antibodies in the Antibody Validation project
St John's Laboratory offers a variety of trial size primary antibodies which target CDKN1A , which are available to try through the Antibody Validation Project. Below we highlight those which have already been reviewed, as well as others which are available to try.
Customer reviewed CDKN1A antibodies
| Model | Name | Host | Clonality | Rating | Application Tested |
|---|---|---|---|---|---|
| STJ94862 | Anti-p21 antibody | Rabbit | Polyclonal | 5 | WB |
| STJ97470 | Anti-p21 antibody | Rabbit | Polyclonal | 4 | WB |
Other CDKN1A antibodies available in the Antibody Validation Project
| Model | Name | Host | Clonality | Recommended Applications |
|---|---|---|---|---|
| STJ90360 | Anti-Phospho-p21 (T145) antibody | Rabbit | Polyclonal | WB,IHC,ELISA |
| STJ94862 | Anti-p21 antibody | Rabbit | Polyclonal | WB,ELISA |
Popular CDKN1A antibodies not currently in the Antibody Validation Project
| Model | Name | Host | Clonality | Recommended Applications |
|---|---|---|---|---|
| STJ111165 | Anti-CDKN1A Antibody | Rabbit | Polyclonal | WB,IHC |
| STJ113149 | Anti-CDKN1A Antibody | Rabbit | Polyclonal | IHC,IF |
| STJ114923 | Anti-CDKN1A Antibody | Rabbit | Monoclonal | WB,IHC,IF,IP |
| STJ160061 | Anti-CDKN1A antibody | Mouse | Monoclonal | IHC |
| STJ180204 | Anti-CDKN1A antibody | Mouse | Monoclonal | IHC |
| STJ22065 | Anti-Phospho-CDKN1A-(T145) Antibody | Rabbit | Polyclonal | IHC |
| STJ23069 | Anti-CDKN1A Antibody | Rabbit | Polyclonal | WB |
| STJ29794 | Anti-CDKN1A Antibody | Rabbit | Polyclonal | WB,IHC,IP |
How does the Antibody Validation Project work?
In order to help our customers with their choice of antibody with low risk, we offer one of the largest ranges of primary antibodies with trial size options available.
The Antibody Validation Project works like this.
1. Order your trial size antibody online.
2. Explore its suitability.
3. Return your results by posting them on the product page.
4. Receive a sample refund.
Find out more here.