Trial size AXL antibodies available in the Antibody Validation Project

Introduction:

The protein encoded by the AXL gene is a member of the TAM receptor tyrosine kinase subfamily and may be responsible for several important cellular functions such as survival, migration and differentiation. In diagnostics it is used as a prognostic marker for unfavourable renal cancer and several mutations of AXL are linked with breast, thyroid and other human cancers. Furthermore, overexpressing of AXL and several other members of the TAM family result in a condition known as LCMV. We provide a number of trial sized antibodies, which are suitable for AXL research purposes, and to help you make the right decision and find the best suited antibody for you, please find the answers to some of the key topics regarding AXL that we have provided in the links below.

• What is AXL?
• Where is AXL found?
• What role does AXL play in disease?
• AXL antibodies in the Antibody Validation project
• Customer reviewed AXL antibodies
• Other AXL antibodies available in the Antibody Validation Project
• Popular AXL antibodies not currently in the Antibody Validation Project
• How does the Antibody Validation Project work?

What is AXL?

The protein encoded by this gene is a member of the Tyro3-Axl-Mer (TAM) receptor tyrosine kinase subfamily, and it possesses an extracellular domain, composed of two immunoglobulin-like motifs at the N-terminal, followed by two fibronectin type-III motifs. It transduces signals from the extracellular matrix into the cytoplasm by binding to the vitamin K-dependent protein growth arrest-specific 6 (Gas6), which is regulating many physiological processes including cell survival, cell proliferation, migration and differentiation. . This gene may be involved in several cellular functions including growth, migration, aggregation and anti-inflammation in multiple cell types. Alternative splicing results in multiple transcript variants of this gene.

Where is AXL found?

Inside the cell, AXL protein is found mainly in the plasma membrane, actin filaments and vesicles. Generally, it has low tissue specificity, but higher levels are found in male-specific tissues.

What role does AXL play in disease?

Several mutations have been reported in breast, thyroid cancer and adenocarcinoma. Apart from that, overexpression of AXL and other members of the TAM family enhance the lymphocytic choriomeningitis(LCMV) infecting rate of cells.

AXL antibodies in the Antibody Validation project

St John's Laboratory offers a variety of trial size primary antibodies which target AXL, which are available to try through the Antibody Validation Project. Below we highlight those which have already been reviewed, as well as others which are available to try.

Customer reviewed AXL antibodies

Model	Name	Host	Clonality	Rating	Application Tested
STJ90939	Anti-Phospho-Axl (Y691) antibody	Rabbit	Polyclonal	4	WB

Other AXL antibodies available in the Antibody Validation Project

Model	Name	Host	Clonality	Recommended Applications
STJ91791	Anti-Axl antibody	Rabbit	Polyclonal	IHC,ELISA
STJ97643	Anti-Axl antibody	Rabbit	Polyclonal	WB,ELISA
STJ97856	Anti-Axl antibody	Mouse	Monoclonal	WB,ELISA
STJ97857	Anti-Axl antibody	Mouse	Monoclonal	WB,IF,ELISA

Popular AXL antibodies not currently in the Antibody Validation Project

Model	Name	Host	Clonality	Recommended Applications
STJ22748	Anti-AXL Antibody	Rabbit	Polyclonal	WB,IHC,FC

How does the Antibody Validation Project work?

In order to help our customers with their choice of antibody with low risk, we offer one of the largest ranges of primary antibodies with trial size options available.

The Antibody Validation Project works like this.
1. Order your trial size antibody online.
2. Explore its suitability.
3. Return your results by posting them on the product page.
4. Receive a sample refund.

Find out more here.