Posted by M.Popov on 12th Nov 2020
Trial size ACTB antibodies available in the Antibody Validation Project
Trial size ACTB antibodies available in the Antibody Validation Project
Abstract:
- What is ACTB?
- Where is ACTB found?
- What role does ACTB play in disease?
- ACTB antibodies in the Antibody Validation project
- Customer reviewed ACTB antibodies
- Other ACTB antibodies available in the Antibody Validation Project
- Popular ACTB antibodies not currently in the Antibody Validation Project
- How does the Antibody Validation Project work?
What is ACTB?
The ACTB gene serves the function to give instructions for synthesizing a protein called beta (β)-actin, part of the actin protein family. These proteins are of a most significant role for determining the shape of the cell and to control motility. Studies suggest that β-actin may also be involved in the process of relaying chemical signals within cells.
Where is ACTB found?
Proteins in the actin protein family are tidied up into a net of fibers named the actin cytoskeleton, which is responsible for the structural framework inside cells. Six types of actin exist- four of them are only in the muscle cells, where they participate in muscle contraction. The rest of the actin proteins, β-actin and gamma (γ)-actin, are found in cells all around the body.
What role does ACTB play in disease?
Several alterations in this gene have been proven to cause Baraitser-Winter syndrome(BWS), a rare condition mainly affecting the development of the brain, eyes, nose and other parts of the face, leading to intellectual instability and in some cases iris or retinal coloboma . The studied mutations transform single protein building blocks (amino acids) into β-actin. The most frequent mutation replaces the amino acid arginine with the amino acid histidine at Arg196His (also known as R196H position). The diagnosis of BWCFF syndrome is established in a proband with a compatible clinical phenotype and a heterozygous gain-of-function variant in either ACTB or ACTG1
ACTB antibodies in the Antibody Validation project
St John's Laboratory offers a variety of trial size primary antibodies which target ACTB, which are available to try through the Antibody Validation Project. Below we highlight those which have already been reviewed, as well as others which are available to try.
Customer reviewed ACTB antibodies
| Model | Name | Host | Clonality | Rating | Application Tested |
|---|---|---|---|---|---|
| STJ91464 | Actin β antibody | Rabbit | Polyclonal | 5 | |
| STJ91464 | Anti-beta Actin antibody | Rabbit | Polyclonal | 4 | WB |
| STJ96930 | Anti-β-actin antibody | Mouse | Monoclonal | 4 | ICC |
| STJ96930 | Anti-β-actin antibody | Mouse | Monoclonal | 5 | WB |
| STJ96941 | Anti-beta actin antibody | Mouse | Monoclonal | 5 | WB |
| STJ96941 | Anti-β-actin antibody | Mouse | Monoclonal | 5 | WB |
| STJ96941 | Anti-β-actin antibody | Mouse | Monoclonal | 5 | WB |
| STJ97089 | Anti-β-actin antibody | Rabbit | Polyclonal | 5 | WB |
Other ACTB antibodies available in the Antibody Validation Project
| Model | Name | Host | Clonality | Recommended Applications |
|---|---|---|---|---|
| STJ140081 | Anti-beta-Actin antibody | Goat | Polyclonal | IF,WB |
| STJ192006 | Anti-ACTB antibody | Rabbit | Polyclonal | WB,ELISA |
| STJ91464 | Anti-Beta Actin antibody | Rabbit | Polyclonal | ELISA,IHC,WB |
| STJ96930 | Anti-beta-actin antibody | Mouse | Monoclonal | FC,IHC,WB |
| STJ96934 | Anti-beta-actin antibody | Mouse | Monoclonal | WB |
| STJ96941 | Anti-beta actin antibody | Mouse | Monoclonal | WB |
| STJ97023 | Anti-beta-actin antibody | Mouse | Monoclonal | WB |
| STJ97035 | Anti-beta-actin antibody | Mouse | Monoclonal | WB |
| STJ97713 | Anti-beta-actin antibody | Rabbit | Polyclonal | WB,IHC |
| STJ97714 | Anti-beta-actin antibody | Rabbit | Polyclonal | WB,IHC |
| STJ97814 | Anti-Actin beta antibody (KLH) | Mouse | Monoclonal | WB,IF,FC,ELISA |
| STJ99027 | Anti-beta-Actin antibody | Mouse | Monoclonal | WB,ELISA |
| STJ99028 | Anti-beta-Actin antibody | Mouse | Monoclonal | WB,ELISA |
| STJ99029 | Anti-beta-Actin antibody | Mouse | Monoclonal | WB,ELISA |
Popular ACTB antibodies not currently in the Antibody Validation Project
| Model | Name | Host | Clonality | Recommended Applications |
|---|---|---|---|---|
| STJ113532 | Anti-ACTB antibody | Rabbit | Monoclonal | WB,IHC |
| STJ116402 | Anti-ACTB antibody | Rabbit | Monoclonal | WB |
| STJ130015 | Anti-beta-Actin antibody | Rabbit | Monoclonal | WB,ELISA,IF |
| STJ130016 | Anti-beta-Actin antibody | Rabbit | Monoclonal | WB,ELISA |
| STJ500039 | Anti-ACTB Antibody | Rabbit | Polyclonal | ELISA,IHC,IP,WB |
| STJ500040 | Anti-ACTB Antibody (Biotin) | Rabbit | Polyclonal | ELISA,IHC,IP,WB |
| STJ500041 | Anti-ACTB Antibody (FITC) | Rabbit | Polyclonal | ELISA,IHC,IP,WB |
| STJ500042 | Anti-ACTB Antibody | Rabbit | Polyclonal | ELISA,IHC,IP,WB |
| STJ500043 | Anti-ACTB Antibody (Biotin) | Rabbit | Polyclonal | ELISA,IHC,IP,WB |
| STJ500044 | Anti-ACTB Antibody (FITC) | Rabbit | Polyclonal | ELISA,IHC,IP,WB |
How does the Antibody Validation Project work?
In order to help our customers with their choice of antibody with low risk, we offer one of the largest ranges of primary antibodies with trial size options available.
The Antibody Validation Project works like this.
1. Order your trial size antibody online.
2. Explore its suitability.
3. Return your results by posting them on the product page.
4. Receive a sample refund.
Find out more here.