Biotinylated Mouse NECTIN4/PVRL4 protein (C-His-Avi) {Biotin} (STJP012878)

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STJP012878-100
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Short Description :Biotinylated Mouse NECTIN4/PVRL4-C-His-Avi protein was developed from mammalian cells and has a target region of C-His-Avi. For use in research applications.
Applications:ELISA/WB
Host:Mammalian Cells
Note:STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Conjugation:Biotin
Dilution Range:Reconstitute in sterile water for a stock solution.
Formulation:Supplied as a 0.22 Mu m filtered solution in 20mM PB, 100mM Arg-HCl, 10% Trehalose, 0.02% Tween 20, pH 7.5.
Storage Instruction:Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for one week. Store at-20 to-80°C for twelve months from the date of receipt.
Endotoxin:< 1 EU/µg as determined by LAL test.
Gene Symbol:Nectin4
Gene ID:71740
Uniprot ID:NECT4_MOUSE
Immunogen:Mus musculus (Mouse)
Immunogen Region:Gly31-Ser349
Function Seems to be involved in cell adhesion through trans-homophilic and -heterophilic interactions, the latter including specifically interactions with NECTIN1. Plays a role in the senescence-associated cell size enlargement via SFK/PI3K/Rac1 and thus promotes senescent cell survival. Also participates in the innate immune response by acting as a ligand for the receptor TIGIT to inhibit NK-cell activity.
Protein Name Nectin-4
Ig Superfamily Receptor Lnir
Nectin Cell Adhesion Molecule 4
Poliovirus Receptor-Related Protein 4
Database Links Reactome: R-MMU-418990
Reactome: -MMU-420597
Cellular Localisation Cell Membrane
Single-Pass Type I Membrane Protein
Cell Junction
Adherens Junction
Colocalizes With Afdn At Cadherin-Based Adherens Junctions
Alternative Protein Names Nectin-4 protein
Ig Superfamily Receptor Lnir protein
Nectin Cell Adhesion Molecule 4 protein
Poliovirus Receptor-Related Protein 4 protein
Nectin4 protein
Lnir protein
Prr4 protein
Pvrl4 protein

Information sourced from Uniprot.org

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