Biotinylated Human CD262/TRAIL-R2/DR5 protein (C-Avi-His) {Biotin} (STJP012344)

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STJP012344-100
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Host: Mammalian Cells
Applications: ELISA/WB
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Biotinylated Human CD262/TRAIL-R2/DR5-C-Avi-His protein was developed from mammalian cells and has a target region of C-Avi-His. For use in research applications.
Conjugation: Biotin
Formulation: Lyophilized from a 0.22 Mu m filtered solution in PBS, pH 7.4.
Dilution Range: Reconstitute in sterile water for a stock solution.
Storage Instruction: Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for one week. Store at-20 to-80°C for twelve months from the date of receipt.
Endotoxin: < 1 EU/µg as determined by LAL test.
Gene Symbol: TNFRSF10B
Gene ID: 8795
Uniprot ID: TR10B_HUMAN
Immunogen Region: Ile56-Glu182
Immunogen: Homo sapiens (Human)
Post Translational Modifications (Microbial infection) Glycosylated on Arg residue by S.typhimurium protein Ssek3.
Function Receptor for the cytotoxic ligand TNFSF10/TRAIL. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. Promotes the activation of NF-kappa-B. Essential for ER stress-induced apoptosis.
Protein Name Tumor Necrosis Factor Receptor Superfamily Member 10b
Death Receptor 5
Tnf-Related Apoptosis-Inducing Ligand Receptor 2
Trail Receptor 2
Trail-R2
Cd Antigen Cd262
Database Links Reactome: R-HSA-140534
Reactome: R-HSA-202733
Reactome: R-HSA-3371378
Reactome: R-HSA-5213460
Reactome: R-HSA-5218900
Reactome: R-HSA-6803211
Reactome: R-HSA-69416
Reactome: R-HSA-75158
Cellular Localisation Membrane
Single-Pass Type I Membrane Protein
Alternative Protein Names Tumor Necrosis Factor Receptor Superfamily Member 10b protein
Death Receptor 5 protein
Tnf-Related Apoptosis-Inducing Ligand Receptor 2 protein
Trail Receptor 2 protein
Trail-R2 protein
Cd Antigen Cd262 protein
TNFRSF10B protein
DR5 protein
KILLER protein
TRAILR2 protein
TRICK2 protein
ZTNFR9 protein
UNQ160 protein
PRO186 protein

Information sourced from Uniprot.org

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