| Applications: |
Immunodepletion/Immunocompetition |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
ASXL1 Blocking Peptide for STJ506146 is synthetically produced from the 1120-1180 sequence and is suitable for use in western blot applications. |
| Formulation: |
Liquid form at 2.5mg/ml concentration in PBS. Up to 5% DMSO can be added. Orders with >1mg can be supplied in lyophilized powder form, or in buffer of choice. |
| Storage Instruction: |
Store at-20°C for long term storage. Avoid freeze-thaw cycles. |
| Gene Symbol: |
Asxl1 |
| Gene ID: |
228790 |
| Uniprot ID: |
ASXL1_MOUSE |
| Immunogen Region: |
1120-1180 |
| Specificity: |
This blocking peptide is recommended for use in combination with ASXL1 antibody, STJ506146 |
| Immunogen: |
Synthetic peptide taken within amino acid region 1120-1180 on mouse Putative Polycomb group protein ASXL1. |
| Post Translational Modifications | Ubiquitinated by TRIP12, leading to its subsequent degradation following binding of N(6)-methyladenine methylated DNA (6mA). |
| Function | Probable Polycomb group (PcG) protein involved in transcriptional regulation mediated by ligand-bound nuclear hormone receptors, such as retinoic acid receptors (RARs) and peroxisome proliferator-activated receptor gamma (PPARG). Acts as a coactivator of RARA and RXRA through association with NCOA1. Acts as a corepressor for PPARG and suppresses its adipocyte differentiation-inducing activity. Non-catalytic component of the PR-DUB complex, a complex that specifically mediates deubiquitination of histone H2A monoubiquitinated at 'Lys-119' (H2AK119ub1). Acts as a sensor of N(6)-methyladenine methylation on DNA (6mA): recognizes and binds 6mA DNA, leading to its ubiquitination and degradation by TRIP12, thereby inactivating the PR-DUB complex and regulating Polycomb silencing. The PR-DUB complex is an epigenetic regulator of gene expression and acts as a transcriptional coactivator, affecting genes involved in development, cell communication, signaling, cell proliferation and cell viability. ASXL1, ASXL2 and ASXL3 function redundantly in the PR-DUB complex. The ASXL proteins are essential for chromatin recruitment and transcriptional activation of associated genes. ASXL1 and ASXL2 are important for BAP1 protein stability. Together with BAP1, negatively regulates epithelial-mesenchymal transition (EMT) of trophoblast stem cells during placental development by regulating genes involved in epithelial cell integrity, cell adhesion and cytoskeletal organization. |
| Peptide Name | Polycomb Group Protein Asxl1Additional Sex Combs-Like Protein 1 |
| Database Links | Reactome: R-MMU-5689603 |
| Cellular Localisation | Nucleus |
| Alternative Peptide Names | Polycomb Group Protein Asxl1 proteinAdditional Sex Combs-Like Protein 1 proteinAsxl1 proteinKiaa0978 protein |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
