Immunofluorescence analysis of paraffin-embedded mouse oophoroma using ZP3 Rabbit polyclonal antibody (STJ115122) at dilution of 1:100. Secondary antibody: Cy3 Goat Anti-Rabbit IgG (H+L) at 1:500 dilution. Blue: DAPI for nuclear staining.

Anti-ZP3 antibody (246-345) (STJ115122)

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STJ115122
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Host: Rabbit
Applications: WB/IF/ICC/ELISA
Reactivity: Human/Mouse/Rat
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Clonality : Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3.
Purification: Affinity purification
Concentration: Lot specific
Dilution Range: WB:1:500-1:2000
IF/ICC:1:50-1:200
ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements.
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: ZP3
Gene ID: 7784
Uniprot ID: ZP3_HUMAN
Immunogen Region: 246-345
Specificity: A synthetic peptide corresponding to a sequence within amino acids 246-345 of human ZP3 (NP_001103824.1).
Immunogen Sequence: DASSAFKVPRPGPDTLQFTV DVFHFANDSRNMIYITCHLK VTLAEQDPDELNKACSFSKP SNSWFPVEGSADICQCCNKG DCGTPSHSRRQPHVMSQWSR
Tissue Specificity Expressed in oocytes (at protein level).
Post Translational Modifications Proteolytically cleaved before the transmembrane segment to yield the secreted ectodomain incorporated in the zona pellucida. N-glycosylated. O-glycosylated.removal of O-linked glycans may play an important role in the post-fertilization block to polyspermy.
Function Component of the zona pellucida, an extracellular matrix surrounding oocytes which mediates sperm binding, induction of the acrosome reaction and prevents post-fertilization polyspermy. The zona pellucida is composed of 3 to 4 glycoproteins, ZP1, ZP2, ZP3, and ZP4. ZP3 is essential for sperm binding and zona matrix formation.
Protein Name Zona Pellucida Sperm-Binding Protein 3
Sperm Receptor
Zp3a/Zp3b
Zona Pellucida Glycoprotein 3
Zp-3
Zona Pellucida Protein C Cleaved Into - Processed Zona Pellucida Sperm-Binding Protein 3
Database Links Reactome: R-HSA-2534343
Cellular Localisation Processed Zona Pellucida Sperm-Binding Protein 3: Zona Pellucida
Cell Membrane
Single-Pass Type I Membrane Protein
Alternative Antibody Names Anti-Zona Pellucida Sperm-Binding Protein 3 antibody
Anti-Sperm Receptor antibody
Anti-Zp3a/Zp3b antibody
Anti-Zona Pellucida Glycoprotein 3 antibody
Anti-Zp-3 antibody
Anti-Zona Pellucida Protein C Cleaved Into - Processed Zona Pellucida Sperm-Binding Protein 3 antibody
Anti-ZP3 antibody
Anti-ZP3A antibody
Anti-ZP3B antibody
Anti-ZPC antibody

Information sourced from Uniprot.org

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